User:Wayne Decatur/SandboxRibosome&Antibiotics
From Proteopedia
(Difference between revisions)
m |
m |
||
| Line 1: | Line 1: | ||
==Interactions between the Ribosome and Antibiotics== | ==Interactions between the Ribosome and Antibiotics== | ||
| - | A major class of [http://en.wikipedia.org/wiki/Antibiotic antibiotics] are those that target protein synthesis. | + | A major class of [http://en.wikipedia.org/wiki/Antibiotic antibiotics] are those that target protein synthesis. Several structures of antibiotics bound to ribosomal subunits and full [[ribosome|ribosomes]] have now revealed at atomic-resolution the details of binding and mechanism of inhibition<ref>PMID: 16553874</ref><ref>PMID: 15491801</ref><ref>PMID: 19929179</ref><ref>PMID: 16261170 </ref><ref>PMID: 16111914</ref><ref>PMID: 15680981</ref>. |
Given the numerous solved structures of antibiotics complexed with ribosomes and ribosomal subunits and the massive size and complexity of the ribosome and the files derived from each structure, several technical and pedagogical issues are obstacles appreciating the elegance and insight provided by these structures. Towards that end this package of pages feature: | Given the numerous solved structures of antibiotics complexed with ribosomes and ribosomal subunits and the massive size and complexity of the ribosome and the files derived from each structure, several technical and pedagogical issues are obstacles appreciating the elegance and insight provided by these structures. Towards that end this package of pages feature: | ||
| - | *Consistent representation and color scheme for the ribosomal subunits, elements and ligands enabling easy visualization of a particular antibiotic binds. | + | *Consistent representation and color scheme for the ribosomal subunits, elements and ligands enabling easy visualization of where a particular antibiotic binds. |
*Links to Proteopedia pages covering the essentials of the structures of each subunit and complete ribosome. | *Links to Proteopedia pages covering the essentials of the structures of each subunit and complete ribosome. | ||
*Data optimized for viewing online in Jmol. This includes limiting much of the files to simply alpha carbon and phosphate atoms and, significantly, combining data split split across multiple PDB coordinate files so the entire ribosome structure is visible at once, an issue the RCSB Protein Data Bank has recently attempted to address, as described [http://www.rcsb.org/pdb/static.do?p=general_information/news_publications/news/news_2009.html#20091208 here]. | *Data optimized for viewing online in Jmol. This includes limiting much of the files to simply alpha carbon and phosphate atoms and, significantly, combining data split split across multiple PDB coordinate files so the entire ribosome structure is visible at once, an issue the RCSB Protein Data Bank has recently attempted to address, as described [http://www.rcsb.org/pdb/static.do?p=general_information/news_publications/news/news_2009.html#20091208 here]. | ||
Revision as of 00:06, 21 December 2009
Interactions between the Ribosome and Antibiotics
A major class of antibiotics are those that target protein synthesis. Several structures of antibiotics bound to ribosomal subunits and full ribosomes have now revealed at atomic-resolution the details of binding and mechanism of inhibition[1][2][3][4][5][6].
Given the numerous solved structures of antibiotics complexed with ribosomes and ribosomal subunits and the massive size and complexity of the ribosome and the files derived from each structure, several technical and pedagogical issues are obstacles appreciating the elegance and insight provided by these structures. Towards that end this package of pages feature:
- Consistent representation and color scheme for the ribosomal subunits, elements and ligands enabling easy visualization of where a particular antibiotic binds.
- Links to Proteopedia pages covering the essentials of the structures of each subunit and complete ribosome.
- Data optimized for viewing online in Jmol. This includes limiting much of the files to simply alpha carbon and phosphate atoms and, significantly, combining data split split across multiple PDB coordinate files so the entire ribosome structure is visible at once, an issue the RCSB Protein Data Bank has recently attempted to address, as described here.
Pages for the Antibiotics bound to the Ribosome
|
|
| ||||||
|
Additional Literature and Resources
- Tenson T, Mankin A. Antibiotics and the ribosome. Mol Microbiol. 2006 Mar;59(6):1664-77. PMID:16553874 doi:10.1111/j.1365-2958.2006.05063.x
- Auerbach T, Bashan A, Yonath A. Ribosomal antibiotics: structural basis for resistance, synergism and selectivity. Trends Biotechnol. 2004 Nov;22(11):570-6. PMID:15491801 doi:10.1016/j.tibtech.2004.09.006
