1upi

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Revision as of 02:09, 25 November 2007

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spinqualitylabelsall models 1upi, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

MYCOBACTERIUM TUBERCULOSIS RMLC EPIMERASE (RV3465)

Overview

The Mycobacterium tuberculosis rmlC gene encodes, dTDP-4-keto-6-deoxyglucose epimerase, the third enzyme in the M., tuberculosis dTDP-L-rhamnose pathway which is essential for mycobacterial, cell-wall synthesis. Because it is structurally unique, highly, substrate-specific and does not require a cofactor, RmlC is considered to, be the most promising drug target in the pathway, and the M. tuberculosis, rmlC gene was selected in the initial round of TB Structural Genomics, Consortium targets for structure determination. The 1.7 A native structure, determined by the consortium facilities is reported and implications for, in silico screening of ligands for structure-guided drug design are, discussed.

About this Structure

1UPI is a Single protein structure of sequence from Mycobacterium tuberculosis. Active as dTDP-4-dehydrorhamnose 3,5-epimerase, with EC number 5.1.3.13 Full crystallographic information is available from OCA.

Reference

Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway., Kantardjieff KA, Kim CY, Naranjo C, Waldo GS, Lekin T, Segelke BW, Zemla A, Park MS, Terwilliger TC, Rupp B, Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):895-902. Epub 2004, Apr 21. PMID:15103135

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