3i81

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 12: Line 12:
===Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide]===
===Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide]===
 +
 +
<!--
 +
The line below this paragraph, {{ABSTRACT_PUBMED_19778024}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 19778024 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_19778024}}
==Disease==
==Disease==
Line 40: Line 46:
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 09:57:51 2009''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Dec 24 07:38:10 2009''

Revision as of 05:38, 24 December 2009

Image:3i81.jpg

Template:STRUCTURE 3i81

Contents

Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide]

Template:ABSTRACT PUBMED 19778024

Disease

Known disease associated with this structure: Insulin-like growth factor I, resistance to OMIM:[147370]

About this Structure

3I81 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Wittman MD, Carboni JM, Yang Z, Lee FY, Antman M, Attar R, Balimane P, Chang C, Chen C, Discenza L, Frennesson D, Gottardis MM, Greer A, Hurlburt W, Johnson W, Langley DR, Li A, Li J, Liu P, Mastalerz H, Mathur A, Menard K, Patel K, Sack J, Sang X, Saulnier M, Smith D, Stefanski K, Trainor G, Velaparthi U, Zhang G, Zimmermann K, Vyas DM. Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem. 2009 Dec 10;52(23):7360-3. PMID:19778024 doi:10.1021/jm900786r

Page seeded by OCA on Thu Dec 24 07:38:10 2009

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3i81"
Personal tools