1yvf

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(New page: 200px<br /><applet load="1yvf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yvf, resolution 2.500&Aring;" /> '''Hepatitis C virus N...)
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Revision as of 02:28, 25 November 2007

Image:1yvf.gif

1yvf, resolution 2.500Å

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Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145

Overview

A novel series of nonnucleoside HCV NS5B polymerase inhibitors were, prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a, high throughput screening lead. SAR studies combined with structure based, drug design focusing on the southern heterobiaryl region of the template, led to the synthesis of several potent and orally bioavailable lead, compounds. X-ray crystallography studies were also performed to understand, the interaction of these inhibitors with HCV NS5B polymerase.

About this Structure

1YVF is a Protein complex structure of sequences from Hepatitis c virus with PO4, CL, PH7 and GOL as ligands. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.

Reference

Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid., Pfefferkorn JA, Greene ML, Nugent RA, Gross RJ, Mitchell MA, Finzel BC, Harris MS, Wells PA, Shelly JA, Anstadt RA, Kilkuskie RE, Kopta LA, Schwende FJ, Bioorg Med Chem Lett. 2005 May 16;15(10):2481-6. PMID:15863301

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