User:Wayne Decatur/Sandbox Thermus 70S With Paromomycin

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<scene name='User:Wayne_Decatur/Sandbox_Thermus_70S_With_Paromomycin/70swithparbest/1'>In the Thermus 70S paromomycin is observed binding to the penultimate helix of the small subunit (helix 44) at the decoding center.</scene>
<scene name='User:Wayne_Decatur/Sandbox_Thermus_70S_With_Paromomycin/70swithparbest/1'>In the Thermus 70S paromomycin is observed binding to the penultimate helix of the small subunit (helix 44) at the decoding center.</scene>
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<scene name='User:Wayne_Decatur/Sandbox_Thermus_70S_With_Paromomycin/70swithparbest/3'>In the Thermus 70S paromomycin is observed binding to the penultimate helix of the small subunit (helix 44) at the decoding center.</scene> WHY IS 5S (:b and 1.1) SHOWING NOT TRANSPARENT!?!?! WASN"T THAT I USED ' color [x777777]' BECAUSE WENT BACK TO USING SAT AND ALTHOUGH IT LOOKS FINE WHEN LOADED IN SAT, WHEN TRIGGERED FROM GREEN LINK IT IS NOT TRANSPARENT?!?!??!? MAybe change all to transparent again and switch back par? I doubt that will help since I used all to change at first anyway, but could try.)
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<scene name='User:Wayne_Decatur/Sandbox_Thermus_70S_With_Paromomycin/70swithparbest/4'>In the Thermus 70S paromomycin is observed binding to the penultimate helix of the small subunit (helix 44) at the decoding center.</scene>
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Add the e. coli 70S that has two molecules bound
Add the e. coli 70S that has two molecules bound
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<!--After much work, finally got 5S to go transparent by turning off cartoon and making it trace. Others seemed fine with cartoon. See
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<scene name='User:Wayne_Decatur/Sandbox_Thermus_70S_With_Paromomycin/70swithparbest/3'>TextToBeDisplayed</scene>-->
==About these Structure==
==About these Structure==
[[2j00]] is a 25 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J00 OCA].
[[2j00]] is a 25 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J00 OCA].

Revision as of 07:11, 9 January 2010

Ribosome interactions with Paromomycin


Contents

Mechanism of action

Drag the structure with the mouse to rotate
 
Drag the structure with the mouse to rotate
REPLACE WITH PAROMOMYCN BOUND TO SMALL SUBUNIT
Paromomycin bound to the ribosome (2j01 and 2j00), resolution 2.8Å ().
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NEED TO DO STILL: SSU alone with PAR


Ramakrishnan one with Par

 
Drag the structure with the mouse to rotate
Paromomycin bound to the ribosome (2j01 and 2j00), resolution 2.8Å ().

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Add the e. coli 70S that has two molecules bound

About these Structure

2j00 is a 25 chains structure of sequences from Escherichia coli and Thermus thermophilus. Full crystallographic information is available from OCA.

2j01 is a 31 chains structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA. Versions of 2j00 and 2j01 optimized for use online as described here are used on this page. You may wish to examine the ADD LINK basics of the subunit.

Reference for the Structures

  • Selmer M, Dunham CM, Murphy FV 4th, Weixlbaumer A, Petry S, Kelley AC, Weir JR, Ramakrishnan V. Structure of the 70S ribosome complexed with mRNA and tRNA. Science. 2006 Sep 29;313(5795):1935-42. Epub 2006 Sep 7. PMID:16959973

Related Structures


[1]

References

  1. ↑ Ogle JM, Carter AP, Ramakrishnan V. Insights into the decoding mechanism from recent ribosome structures. Trends Biochem Sci. 2003 May;28(5):259-66. PMID:12765838

Additional Literature and Resources

  • Auerbach T, Bashan A, Yonath A. Ribosomal antibiotics: structural basis for resistance, synergism and selectivity. Trends Biotechnol. 2004 Nov;22(11):570-6. PMID:15491801 doi:10.1016/j.tibtech.2004.09.006

Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur

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