3i5n

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3i5n.jpg|left|200px]]
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The entry 3i5n is ON HOLD until Paper Publication
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{{STRUCTURE_3i5n| PDB=3i5n | SCENE= }}
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Authors: Bellon, S.F., Whittington, D.A., Long, A.M., Boezio, A.A.
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===Crystal structure of c-Met with triazolopyridazine inhibitor 13===
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Description: Crystal structure of c-Met with triazolopyridazine inhibitor 13
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 09:47:43 2009''
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(as it appears on PubMed at http://www.pubmed.gov), where 19819693 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19819693}}
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==Disease==
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Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]]
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==About this Structure==
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3I5N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5N OCA].
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==Reference==
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<ref group="xtra">PMID:19819693</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Bellon, S F.]]
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[[Category: Boezio, A A.]]
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[[Category: Long, A M.]]
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[[Category: Whittington, D A.]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Chromosomal rearrangement]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Hgf/sf]]
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[[Category: Kinase]]
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[[Category: Membrane]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Proto-oncogene]]
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[[Category: Receptor]]
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[[Category: Receptor tyrosine kinase]]
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[[Category: Rtk]]
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[[Category: Scatter factor receptor]]
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[[Category: Transferase]]
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[[Category: Transmembrane]]
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[[Category: Tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 13:54:31 2010''

Revision as of 11:54, 13 January 2010

Image:3i5n.jpg

Template:STRUCTURE 3i5n

Contents

Crystal structure of c-Met with triazolopyridazine inhibitor 13

Template:ABSTRACT PUBMED 19819693

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

3I5N is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Boezio AA, Berry L, Albrecht BK, Bauer D, Bellon SF, Bode C, Chen A, Choquette D, Dussault I, Fang M, Hirai S, Kaplan-Lefko P, Larrow JF, Lin MH, Lohman J, Potashman MH, Qu Y, Rex K, Santostefano M, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Harmange JC. Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6307-12. Epub 2009 Sep 27. PMID:19819693 doi:10.1016/j.bmcl.2009.09.096

Page seeded by OCA on Wed Jan 13 13:54:31 2010

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