1z27

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(New page: 200px<br /><applet load="1z27" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z27, resolution 2.08&Aring;" /> '''Crystal structure of...)
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Revision as of 02:34, 25 November 2007

Image:1z27.gif

1z27, resolution 2.08Å

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Crystal structure of Native Pvs25, an ookinete protein from Plasmodium vivax.

Overview

P25 and P28 proteins are essential for Plasmodium parasites to infect, mosquitoes and are leading candidates for a transmission-blocking malaria, vaccine. The Plasmodium vivax P25 is a triangular prism that could tile, the parasite surface. The residues forming the triangle are conserved in, P25 and P28 from all Plasmodium species. A cocrystal structure shows that, a transmission-blocking antibody uses only its heavy chain to bind Pvs25, at a vertex of the triangle.

About this Structure

1Z27 is a Single protein structure of sequence from Plasmodium vivax. Full crystallographic information is available from OCA.

Reference

The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807

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