User:Karl Oberholser/Sandbox 1

From Proteopedia

proteopedia linkproteopedia link

Revision as of 14:21, 13 January 2010 (edit) Karl Oberholser (Talk | contribs) (→Pyrimidine Nucleosides) ← Previous diff		Revision as of 15:21, 13 January 2010 (edit) (undo) Karl Oberholser (Talk | contribs) Next diff →
Line 10:		Line 10:
	== Pyrimidine Nucleosides ==		== Pyrimidine Nucleosides ==
	<scene name='User:Karl_Oberholser/Sandbox_1/Anti_uridine/1'>View</scene> of uridine in the anti conformation. <scene name='User:Karl_Oberholser/Sandbox_1/Syn_cytidine/1'>View</scene> of cytidine in the syn conformation. <scene name='User:Karl_Oberholser/Sandbox_1/Syn_cytidine2/1'>View</scene> sterically hindered oxygen at the C-2 position of cytidine in the syn conformation. Since both pyrimidines found in DNA have an oxygen at the C-2 position, nucleosides and nucleotides of these pyrimidines only adopt the anti conformation and therefore can not be part of Z-DNA.		<scene name='User:Karl_Oberholser/Sandbox_1/Anti_uridine/1'>View</scene> of uridine in the anti conformation. <scene name='User:Karl_Oberholser/Sandbox_1/Syn_cytidine/1'>View</scene> of cytidine in the syn conformation. <scene name='User:Karl_Oberholser/Sandbox_1/Syn_cytidine2/1'>View</scene> sterically hindered oxygen at the C-2 position of cytidine in the syn conformation. Since both pyrimidines found in DNA have an oxygen at the C-2 position, nucleosides and nucleotides of these pyrimidines only adopt the anti conformation and therefore can not be part of Z-DNA.
		+
		+	== Examples of Nucleotides ==
		+	AMP <scene name='User:Karl_Oberholser/Sandbox_1/Amp/1'>as ball and stick</scene>; <scene name='User:Karl_Oberholser/Sandbox_1/Amp2/1'>as spacefill</scene>
		+
		+	UMP <scene name='User:Karl_Oberholser/Sandbox_1/Ump/1'>as ball and stick</scene>; <scene name='User:Karl_Oberholser/Sandbox_1/Ump2/1'>as spacefill</scene>
		+
		+	cAMP <scene name='User:Karl_Oberholser/Sandbox_1/Camp/1'>as ball and stick</scene>; <scene name='User:Karl_Oberholser/Sandbox_1/Camp2/1'>as spacefill</scene>

---

Revision as of 15:21, 13 January 2010

This page contains material that is currently being developed.

Contents 1 Syn and Anti Configurations of Nucleosides and Nucleotides 2 Purine Nucleosides 3 Pyrimidine Nucleosides 4 Examples of Nucleotides

Syn and Anti Configurations of Nucleosides and Nucleotides

Detailed description of nucleosides and nucleotides.

Purine Nucleosides

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Observe that the adenine ring of adenosine is nearly perpendicular to the furanose ring and that a (colored green) connects adenine to ribofuranose. Groups on the ribofuranose, such as the on the 2' carbon sterically hinder the rotation of the adenine about the glycosidic bond. This lack of ability to rotate results in two possible configurations. The anti configuration, which you have been viewing, but now in and the , , same view but in . With purines the anti configuration is favored, but the syn configuration can be assumed and actually has a role in the formation of the Z-DNA, a conformation of DNA double helix.

Pyrimidine Nucleosides

of uridine in the anti conformation. of cytidine in the syn conformation. sterically hindered oxygen at the C-2 position of cytidine in the syn conformation. Since both pyrimidines found in DNA have an oxygen at the C-2 position, nucleosides and nucleotides of these pyrimidines only adopt the anti conformation and therefore can not be part of Z-DNA.

Examples of Nucleotides

AMP ;

UMP ;

cAMP ;