User:Karl Oberholser/Sandbox 1

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	== Pyrimidine Nucleosides ==		== Pyrimidine Nucleosides ==
-	<scene name='User:Karl_Oberholser/Sandbox_1/Anti_uridine/1'>View</scene> of uridine in the anti conformation. <scene name='User:Karl_Oberholser/Sandbox_1/Syn_cytidine/1'>View</scene> of cytidine in the syn conformation. <scene name='User:Karl_Oberholser/Sandbox_1/Syn_cytidine2/2'>View</scene> sterically hindered oxygen at the C-2 position of cytidine in the syn conformation. Since both pyrimidines found in DNA have an oxygen at the C-2 position, nucleosides and nucleotides of these pyrimidines only adopt the anti conformation and therefore can not be part of Z-DNA.	+	<scene name='User:Karl_Oberholser/Sandbox_1/Anti_uridine/1'>View</scene> of uridine in the anti conformation. <scene name='User:Karl_Oberholser/Sandbox_1/Syn_cytidine/1'>View</scene> of cytidine in the syn conformation. <scene name='User:Karl_Oberholser/Sandbox_1/Syn_cytidine2/4'>View</scene> oxygen at the C-2 position of cytidine invading the space of both hydrogen at C-2' and the oxygen of the furanose ring. Since both pyrimidines found in DNA have an oxygen at the C-2 position, nucleosides and nucleotides of these pyrimidines only adopt the anti conformation and therefore can not be part of Z-DNA.
	== Examples of Nucleotides ==		== Examples of Nucleotides ==

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Revision as of 16:37, 13 January 2010

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Contents 1 Syn and Anti Configurations of Nucleosides and Nucleotides 2 Purine Nucleosides 3 Pyrimidine Nucleosides 4 Examples of Nucleotides

Syn and Anti Configurations of Nucleosides and Nucleotides

Detailed description of nucleosides and nucleotides.

Purine Nucleosides

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Observe that the adenine ring of adenosine is nearly perpendicular to the furanose ring and that a (colored green) connects adenine to ribofuranose. Groups on the ribofuranose, such as the on the 2' carbon sterically hinder the rotation of the adenine about the glycosidic bond. This lack of ability to rotate results in two possible configurations. The anti configuration, which you have been viewing, but now in and the , , same view but in . With purines the anti configuration is favored, but the syn configuration can be assumed and actually has a role in the formation of the Z-DNA, a conformation of DNA double helix.

Pyrimidine Nucleosides

of uridine in the anti conformation. of cytidine in the syn conformation. oxygen at the C-2 position of cytidine invading the space of both hydrogen at C-2' and the oxygen of the furanose ring. Since both pyrimidines found in DNA have an oxygen at the C-2 position, nucleosides and nucleotides of these pyrimidines only adopt the anti conformation and therefore can not be part of Z-DNA.

Examples of Nucleotides

AMP ;

UMP ;

cAMP ;