User:Karl Oberholser/Sandbox 1
From Proteopedia
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== Purine Nucleosides == | == Purine Nucleosides == | ||
| - | <applet load='Adenosine.pdb' size='300' frame='true' align='right' scene ='User:Karl_Oberholser/Sandbox_1/First_view/1'/> Observe that the adenine ring of adenosine is nearly perpendicular to the furanose ring and that a <scene name='User:Karl_Oberholser/Sandbox_1/Glycosidic_bond/1'>β glycosidic bond</scene> (colored green) connects adenine to ribofuranose. Groups on the ribofuranose, such as the <scene name='User:Karl_Oberholser/Sandbox_1/2_hydrogen/1'>hydrogen</scene> on the 2' carbon sterically hinder the rotation of the adenine about the glycosidic bond. This lack of ability to rotate results in two possible configurations. The anti configuration, which you have been viewing, but now in <scene name='User:Karl_Oberholser/Sandbox_1/Anti_configuration/2'>spacefill</scene> and the <scene name='User:Karl_Oberholser/Sandbox_1/Syn_configuration/1'>syn configuration</scene>, <scene name='User:Karl_Oberholser/Sandbox_1/Syn_configuration2/1'>view of adenine ring on edge</scene>, same view but in <scene name='User:Karl_Oberholser/Sandbox_1/Syn_configuration3/1'>spacefill</scene>. With purines the anti configuration is favored, but the syn configuration can be | + | <applet load='Adenosine.pdb' size='300' frame='true' align='right' scene ='User:Karl_Oberholser/Sandbox_1/First_view/1'/> Observe that the adenine ring of adenosine is nearly perpendicular to the furanose ring and that a <scene name='User:Karl_Oberholser/Sandbox_1/Glycosidic_bond/1'>β glycosidic bond</scene> (colored green) connects adenine to ribofuranose. Groups on the ribofuranose, such as the <scene name='User:Karl_Oberholser/Sandbox_1/2_hydrogen/1'>hydrogen</scene> on the 2' carbon sterically hinder the rotation of the adenine about the glycosidic bond. This lack of ability to rotate results in two possible configurations. The anti configuration, which you have been viewing, but now in <scene name='User:Karl_Oberholser/Sandbox_1/Anti_configuration/2'>spacefill</scene> and the <scene name='User:Karl_Oberholser/Sandbox_1/Syn_configuration/1'>syn configuration</scene>, <scene name='User:Karl_Oberholser/Sandbox_1/Syn_configuration2/1'>view of adenine ring on edge</scene>, same view but in <scene name='User:Karl_Oberholser/Sandbox_1/Syn_configuration3/1'>spacefill</scene>. With purines the anti configuration is favored, but the syn configuration can be formed and actually has a role in the formation of the [http://proteopedia.org/wiki/index.php/Z-DNA Z-DNA], a conformation of DNA double helix. |
== Pyrimidine Nucleosides == | == Pyrimidine Nucleosides == | ||
Revision as of 18:12, 13 January 2010
This page contains material that is currently being developed.
Contents |
Syn and Anti Configurations of Nucleosides and Nucleotides
Detailed description of nucleosides and nucleotides.
Purine Nucleosides
|
Pyrimidine Nucleosides
of uridine in the anti conformation. of cytidine in the syn conformation. oxygen at the C-2 position of cytidine invading the space of both hydrogen at C-2' and the oxygen of the furanose ring. Since both pyrimidines found in DNA have an oxygen at the C-2 position, nucleosides and nucleotides of these pyrimidines only adopt the anti conformation and therefore can not be part of Z-DNA.
Examples of Nucleotides
AMP ;
UMP ;
cAMP ;
