2zgd

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===Asn-hydroxylation stabilises the ankyrin repeat domain fold===
===Asn-hydroxylation stabilises the ankyrin repeat domain fold===
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{{ABSTRACT_PUBMED_19081931}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:17573339</ref><ref group="xtra">PMID:17003112</ref><references group="xtra"/>
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<ref group="xtra">PMID:19081931</ref><ref group="xtra">PMID:17573339</ref><ref group="xtra">PMID:17003112</ref><references group="xtra"/>
[[Category: McDonough, M A.]]
[[Category: McDonough, M A.]]
[[Category: Schofield, C J.]]
[[Category: Schofield, C J.]]
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[[Category: Hydroxylated]]
[[Category: Hydroxylated]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 20:55:48 2009''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jan 18 09:14:20 2010''

Revision as of 07:14, 18 January 2010

Image:2zgd.png

Template:STRUCTURE 2zgd

Asn-hydroxylation stabilises the ankyrin repeat domain fold

Template:ABSTRACT PUBMED 19081931

About this Structure

2ZGD is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kelly L, McDonough MA, Coleman ML, Ratcliffe PJ, Schofield CJ. Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. Mol Biosyst. 2009 Jan;5(1):52-8. Epub 2008 Oct 29. PMID:19081931 doi:10.1039/b815271c
  • Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem. 2007 Aug 17;282(33):24027-38. Epub 2007 Jun 15. PMID:17573339 doi:http://dx.doi.org/10.1074/jbc.M704102200
  • Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. Epub 2006 Sep 26. PMID:17003112

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