1cvl
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1CVL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Chromobacterium_viscosum Chromobacterium viscosum]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ | + | 1CVL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Chromobacterium_viscosum Chromobacterium viscosum]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3]]. Structure known Active Sites: ACT, CA and OXY. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CVL OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Chromobacterium viscosum]] | [[Category: Chromobacterium viscosum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Triacylglycerol lipase]] | ||
[[Category: Haalck, L.]] | [[Category: Haalck, L.]] | ||
[[Category: Hecht, H.J.]] | [[Category: Hecht, H.J.]] | ||
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[[Category: x-ray crystallography]] | [[Category: x-ray crystallography]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:03:13 2007'' |
Revision as of 07:58, 30 October 2007
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CRYSTAL STRUCTURE OF BACTERIAL LIPASE FROM CHROMOBACTERIUM VISCOSUM ATCC 6918
Overview
The crystal structure of a lipase from the bacterium Chromobacterium, viscosum ATCC 6918 (CVL) has been determined by isomorphous replacement, and refined at 1.6 angstroms resolution to an R-factor of 17.8%. The, lipase has the overall topology of an alpha/beta type protein, which was, also found for previously determined lipase structures. The catalytic, triad of the active center consists of the residues Ser87, Asp263 and, His285. These residues are not exposed to the solvent, but a narrow, channel connects them with the molecular surface. This conformation is, very similar to the previously reported closed conformation of Pseudomonas, glumae lipase (PGL), but superposition of the two lipase structures, reveals several conformational differences. r.m.s. deviations greater than, 2 ... [(full description)]
About this Structure
1CVL is a [Single protein] structure of sequence from [Chromobacterium viscosum] with CA as [ligand]. Active as [Triacylglycerol lipase], with EC number [3.1.1.3]. Structure known Active Sites: ACT, CA and OXY. Full crystallographic information is available from [OCA].
Reference
Crystal structure of a bacterial lipase from Chromobacterium viscosum ATCC 6918 refined at 1.6 angstroms resolution., Lang D, Hofmann B, Haalck L, Hecht HJ, Spener F, Schmid RD, Schomburg D, J Mol Biol. 1996 Jun 21;259(4):704-17. PMID:8683577
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