3kga

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3kga.jpg|left|200px]]
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The entry 3kga is ON HOLD until Paper Publication
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{{STRUCTURE_3kga| PDB=3kga | SCENE= }}
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Authors: Kroemer, M., Velcicky, J., Izaac, A., Be, C., Huppertz, C., Pflieger, D., Schlapbach, A., Scheufler, C.
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===Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor===
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Description: Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:12:41 2009''
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(as it appears on PubMed at http://www.pubmed.gov), where 20060294 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20060294}}
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==About this Structure==
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3KGA is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGA OCA].
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==Reference==
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<ref group="xtra">PMID:20060294</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Be, C.]]
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[[Category: Huppertz, C.]]
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[[Category: Izaac, A.]]
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[[Category: Kroemer, M.]]
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[[Category: Pflieger, D.]]
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[[Category: Scheufler, C.]]
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[[Category: Schlapbach, A.]]
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[[Category: Velcicky, J.]]
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[[Category: 3-aminopyrazole scaffold]]
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[[Category: Activation loop deletion]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Atp-site kinase inhibitor]]
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[[Category: Induced fit]]
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[[Category: Kinase]]
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[[Category: Novel hydrophobic pocket]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Scaffold hoping]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Small molecule inhibitor]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:45:42 2010''

Revision as of 17:45, 27 January 2010

Image:3kga.jpg

Template:STRUCTURE 3kga

Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor

Template:ABSTRACT PUBMED 20060294

About this Structure

3KGA is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Velcicky J, Feifel R, Hawtin S, Heng R, Huppertz C, Koch G, Kroemer M, Moebitz H, Revesz L, Scheufler C, Schlapbach A. Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1293-7. Epub 2009 Nov 3. PMID:20060294 doi:10.1016/j.bmcl.2009.10.138

Page seeded by OCA on Wed Jan 27 19:45:42 2010

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