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2x0v

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===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE===
===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE===
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{{ABSTRACT_PUBMED_20142040}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:20142040</ref><ref group="xtra">PMID:17015838</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Basse, N.]]
[[Category: Basse, N.]]
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[[Category: Joerger, A C.]]
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[[Category: Kaar, J L.]]
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[[Category: Apoptosis]]
[[Category: Apoptosis]]
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[[Category: Tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:55:36 2010''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 09:33:09 2010''

Revision as of 07:33, 25 February 2010

Image:2x0v.png

Template:STRUCTURE 2x0v

STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE

Template:ABSTRACT PUBMED 20142040

About this Structure

2X0V is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29;17(1):46-56. PMID:20142040 doi:10.1016/j.chembiol.2009.12.011
  • Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838

Page seeded by OCA on Thu Feb 25 09:33:09 2010

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