2x0v
From Proteopedia
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===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE=== | ===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE=== | ||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Basse, N.]] | [[Category: Basse, N.]] | ||
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[[Category: Joerger, A C.]] | [[Category: Joerger, A C.]] | ||
[[Category: Kaar, J L.]] | [[Category: Kaar, J L.]] | ||
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[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Cancer]] | [[Category: Cancer]] | ||
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[[Category: Tumor suppressor]] | [[Category: Tumor suppressor]] | ||
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Revision as of 07:33, 25 February 2010
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE
Template:ABSTRACT PUBMED 20142040
About this Structure
2X0V is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29;17(1):46-56. PMID:20142040 doi:10.1016/j.chembiol.2009.12.011
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
Page seeded by OCA on Thu Feb 25 09:33:09 2010
Categories: Homo sapiens | Basse, N. | Fersht, A R. | Joerger, A C. | Kaar, J L. | Apoptosis | Cancer | Cell cycle | Host-virus interaction | Li-fraumeni drug discovery | Metal binding | Protein stabilization | Surface crevice | Transcription | Transcription factor | Transcription regulation | Tumor suppressor
