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Fructose Bisphosphate Aldolase
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'''Fructose biphosphate aldolase''' | '''Fructose biphosphate aldolase''' | ||
| - | Fructose biphosphate aldolase is an enzyme in glycolysis. It catalyzes the breakdown of fructose-1,6-biophosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-2-phosphate (GAP). The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation. Catalysis occurs by the formation of a Schiff base (an imine resulting from a ketone and amine) from the amine of the aldolase's Lys229 and the open-ring form of FBP accompanied by stabilization from Asp33. <scene name='Austin_Drake_Sandbox/Catalytic_site/1'>Catalytic Site</scene> <ref name="jmol">Jmol: an open-source Java viewer for chemical structures in 3D. http://www.jmol.org/<ref/> Aldol cleavage produces GAP and an enamine precursor to DHAP. Tautomerization, protonation and the hydrolysis of the Schiff base produce the final product of DHAP and the active enzyme.<ref>Voet, D, Voet, J, & Pratt, C. (2008). Fundamentals of biochemistry, third edition. Hoboken, NJ: Wiley & Sons, Inc.<ref/> | + | Fructose biphosphate aldolase is an enzyme in glycolysis. It catalyzes the breakdown of fructose-1,6-biophosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-2-phosphate (GAP). The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation. Catalysis occurs by the formation of a Schiff base (an imine resulting from a ketone and amine) from the amine of the aldolase's Lys229 and the open-ring form of FBP accompanied by stabilization from Asp33. <scene name='Austin_Drake_Sandbox/Catalytic_site/1'>Catalytic Site</scene> <ref name="jmol"> Jmol: an open-source Java viewer for chemical structures in 3D. http://www.jmol.org/<ref/> Aldol cleavage produces GAP and an enamine precursor to DHAP. Tautomerization, protonation and the hydrolysis of the Schiff base produce the final product of DHAP and the active enzyme.<ref>Voet, D, Voet, J, & Pratt, C. (2008). Fundamentals of biochemistry, third edition. Hoboken, NJ: Wiley & Sons, Inc.<ref/> |
<scene name='Austin_Drake_Sandbox/B_sheet_barrel/2'>FBP fits here</scene><refname="jmol" /> | <scene name='Austin_Drake_Sandbox/B_sheet_barrel/2'>FBP fits here</scene><refname="jmol" /> | ||
Revision as of 02:15, 26 February 2010
Fructose biphosphate aldolase Fructose biphosphate aldolase is an enzyme in glycolysis. It catalyzes the breakdown of fructose-1,6-biophosphate into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-2-phosphate (GAP). The reaction is an aldol cleavage, or otherwise termed, retro aldo condensation. Catalysis occurs by the formation of a Schiff base (an imine resulting from a ketone and amine) from the amine of the aldolase's Lys229 and the open-ring form of FBP accompanied by stabilization from Asp33. [1]
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