Phosphoglucoisomerase

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Phosphoglucoisomerase is also know for a list of activities outside the cells:
Phosphoglucoisomerase is also know for a list of activities outside the cells:
* Neuroleukin (NLK)- nerve growth factor secreted by T cells, also used to stimulate the production of immunoglobulin.
* Neuroleukin (NLK)- nerve growth factor secreted by T cells, also used to stimulate the production of immunoglobulin.
-
* Autocrine motility factor (AMF)- product of tumor cells, it promotes cell migration and viewed as a possible cause in cancer metastasis.
+
* Autocrine motility factor (AMF)- product of tumor cells, it promotes cell migration and viewed as a possible cause in cancer metastasis<ref>PMID:12054796</ref>.
* Maturation factor(MF)
* Maturation factor(MF)
* Myofibril-bound serine protese inhibitor (MBSPI)
* Myofibril-bound serine protese inhibitor (MBSPI)

Revision as of 22:34, 28 February 2010

Human phosphoglucose isomerase (1IAT)

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Phosphoglucoisomerase (alternatively known as phosphoglucose isomerase or Glucose-6-phosphate isomerase) are a group of enzymes of the isomerase family (EC 5.3.1.9), so named for their main function in glycolysis and gluconeogenesis. In both these pathways phosphoglucose isomerase (PGI) is used to inter-convert glucose-6-phosphate and fructose 6-phosphate, reaction driven by the relative concentrations of these sugars in the cytoplasmic matrix of the cell.

Phosphoglucoisomerase is also know for a list of activities outside the cells:

  • Neuroleukin (NLK)- nerve growth factor secreted by T cells, also used to stimulate the production of immunoglobulin.
  • Autocrine motility factor (AMF)- product of tumor cells, it promotes cell migration and viewed as a possible cause in cancer metastasis[1].
  • Maturation factor(MF)
  • Myofibril-bound serine protese inhibitor (MBSPI)

Contents

Structure

Phosphoglucose isomerase dimer(1HOX)

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Mechanism

Image:Mech.png

Links

  • Crystal Structure of human phosphoglucose isomerase (PDB=1iat[2])
  • Crystal Structure of rabbit phosphoglucose isomerase complexed fructose 6-phosphate (PDB=1hox[3])

References

  1. ↑ Tanaka N, Haga A, Uemura H, Akiyama H, Funasaka T, Nagase H, Raz A, Nakamura KT. Inhibition mechanism of cytokine activity of human autocrine motility factor examined by crystal structure analyses and site-directed mutagenesis studies. J Mol Biol. 2002 May 10;318(4):985-97. PMID:12054796 doi:10.1016/S0022-2836(02)00186-9
  2. ↑ Read J, Pearce J, Li X, Muirhead H, Chirgwin J, Davies C. The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia. J Mol Biol. 2001 Jun 1;309(2):447-63. PMID:11371164 doi:10.1006/jmbi.2001.4680
  3. ↑ Lee JH, Chang KZ, Patel V, Jeffery CJ. Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate. Biochemistry. 2001 Jul 3;40(26):7799-805. PMID:11425306
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