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Jasper Small Lactate Sandbox 1

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===HUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE===
===HUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE===
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==Lactate Dehydrogenase==
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Lactate Dehydrogenase (LDH) is an important enzyme in humans. It occurs in different regions of the body, each region having a unique conformation of different subunits. The Jmole image shown is that of LDH-5, the form found in skeleton muscle and the liver.
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{{ABSTRACT_PUBMED_11276087}}
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==Disease==
==Disease==
Known disease associated with this structure: Exertional myoglobinuria due to deficiency of LDH-A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=150000 150000]]
Known disease associated with this structure: Exertional myoglobinuria due to deficiency of LDH-A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=150000 150000]]

Revision as of 21:39, 1 March 2010


PDB ID 1i10

Drag the structure with the mouse to rotate
1i10, resolution 2.30Å ()
Ligands: , ,
Gene: LDHA (Homo sapiens)
Activity: L-lactate dehydrogenase, with EC number 1.1.1.27
Related: 1i0z, 9ldt, 5ldh, 1ldg
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

HUMAN MUSCLE L-LACTATE DEHYDROGENASE M CHAIN, TERNARY COMPLEX WITH NADH AND OXAMATE

Lactate Dehydrogenase

Lactate Dehydrogenase (LDH) is an important enzyme in humans. It occurs in different regions of the body, each region having a unique conformation of different subunits. The Jmole image shown is that of LDH-5, the form found in skeleton muscle and the liver.

Disease

Known disease associated with this structure: Exertional myoglobinuria due to deficiency of LDH-A OMIM:[150000]

About this Structure

1I10 is a 8 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Read JA, Winter VJ, Eszes CM, Sessions RB, Brady RL. Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase. Proteins. 2001 May 1;43(2):175-85. PMID:11276087

Page seeded by OCA on Tue Feb 17 09:19:04 2009

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