1a8b
From Proteopedia
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| - | [[Image:1a8b.gif|left|200px]]<br /> | + | [[Image:1a8b.gif|left|200px]]<br /><applet load="1a8b" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1a8b" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1a8b, resolution 1.9Å" /> | caption="1a8b, resolution 1.9Å" /> | ||
'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE'''<br /> | '''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1A8B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA and GPE as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 1A8B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA and GPE as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=GPE:Gpe Binding Site (Includes 1 Ca Ion)'>GPE</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A8B OCA]. |
==Reference== | ==Reference== | ||
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[[Category: phospholipid analog]] | [[Category: phospholipid analog]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:10:48 2007'' |
Revision as of 12:01, 18 December 2007
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RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE
Overview
Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as, annexins, protein kinase C, and certain coagulation proteins. Crystal, structures of Ca(2+)-annexin V complexes with phospholipid polar heads, provide molecular details of 'Ca(2+)-bridges' as key features in the, membrane attachment exhibited by these proteins. Distinct binding sites, for phospholipid head groups are observed, including a novel, double-Ca2+, recognition site for phosphoserine that may serve as a phosphatidylserine, receptor site in vivo.
About this Structure
1A8B is a Single protein structure of sequence from Rattus norvegicus with CA and GPE as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670
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