Gramicidin Channel in Lipid Bilayer

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (I favor these simpler links)
Line 20: Line 20:
</li><li>
</li><li>
Show only
Show only
-
<scene name='Gramicidin_Channel_in_Lipid_Bilayer/Two_pes_two_waters/1'>2 phospholipids and 2 waters</scene>. For an explanation of their structure, see the [http://www2.uah.es/biomodel/en/model2/bilayer/inicio.htm detailed tutorial].
+
<scene name='Gramicidin_Channel_in_Lipid_Bilayer/Two_pes_two_waters/1'>2 phospholipids and 2 waters</scene>. For an explanation of their structure, see the [http://biomodel.uah.es/en/model2/bilayer detailed tutorial].
</li>
</li>
</ul>
</ul>
Line 28: Line 28:
{{Clear}}
{{Clear}}
==See Also==
==See Also==
-
* A detailed explanation and tutorial about [http://www2.uah.es/biomodel/en/model2/bilayer/inicio.htm Lipid Bilayers and the Gramicidin Channel].
+
* A detailed explanation and tutorial about [http://biomodel.uah.es/en/model2/bilayer Lipid Bilayers and the Gramicidin Channel].
* [http://firstglance.jmol.org/fg.htm?mol=http://proteopedia.org/wiki/images/f/fd/Gramicidin_in_bilayer.pdb.gz This model in FirstGlance in Jmol]. Be sure to click the ''Ligands+'' and ''Water'' buttons!
* [http://firstglance.jmol.org/fg.htm?mol=http://proteopedia.org/wiki/images/f/fd/Gramicidin_in_bilayer.pdb.gz This model in FirstGlance in Jmol]. Be sure to click the ''Ligands+'' and ''Water'' buttons!
* [http://bme3d.molviz.org/ BioMolecular Explorer 3D], a resource for high school teachers that includes a section on gramicidin in a lipid bilayer.
* [http://bme3d.molviz.org/ BioMolecular Explorer 3D], a resource for high school teachers that includes a section on gramicidin in a lipid bilayer.

Revision as of 14:33, 5 March 2010

Theoretical Model: The structure described on this page was determined theoretically, and hence should be interpreted with caution.

Theoretical model of gramicidin in a lipid bilayer (phosphatidyl ethanolamine).

Drag the structure with the mouse to rotate

Two copies of the gramicidin protein are shown here () arranged as they are believed to be when they form a channel through a lipid bilayer membrane[1]. The shape of the protein is shown transparent (ghostly), and a backbone trace connecting the alpha carbon atoms of each amino acid chain is opaque (solid).

  • Show of the gramicidin protein chains.
  • (Most hydrogen atoms are omitted.)
  • Show . Notice how the hydrophobic lipid "tails" exclude water.
  • Water passes .
  • Show .

  • Show only . For an explanation of their structure, see the detailed tutorial.

Remember to use the popup button and then resize the popup window to enlarge the molecular scenes.

See Also

Notes

References

  1. Crouzy S, Woolf TB, Roux B. A molecular dynamics study of gating in dioxolane-linked gramicidin A channels. Biophys J. 1994 Oct;67(4):1370-86. PMID:7529578 doi:http://dx.doi.org/10.1016/S0006-3495(94)80618-6

Proteopedia Page Contributors and Editors (what is this?)

Eric Martz, Angel Herraez, David Canner, Jaime Prilusky

Personal tools