1azs
From Proteopedia
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| - | [[Image:1azs. | + | [[Image:1azs.jpg|left|200px]]<br /><applet load="1azs" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1azs" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1azs, resolution 2.3Å" /> | caption="1azs, resolution 2.3Å" /> | ||
'''COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE'''<br /> | '''COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AZS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with MG, GSP and FKP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] | + | 1AZS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with MG, GSP and FKP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] Known structural/functional Site: <scene name='pdbsite=MGB:Mg Binding Site In Active Site Of Adenylyl Cyclase'>MGB</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AZS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: signal transducing protein]] | [[Category: signal transducing protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:24:15 2007'' |
Revision as of 12:14, 18 December 2007
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE
Overview
The crystal structure of a soluble, catalytically active form of adenylyl, cyclase in a complex with its stimulatory heterotrimeric G protein alpha, subunit (Gsalpha) and forskolin was determined to a resolution of 2.3, angstroms. When P-site inhibitors were soaked into native crystals of the, complex, the active site of adenylyl cyclase was located and structural, elements important for substrate recognition and catalysis were, identified. On the basis of these and other structures, a molecular, mechanism is proposed for the activation of adenylyl cyclase by Gsalpha.
About this Structure
1AZS is a Protein complex structure of sequences from Bos taurus, Canis lupus familiaris and Rattus norvegicus with MG, GSP and FKP as ligands. Active as Adenylate cyclase, with EC number 4.6.1.1 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS., Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR, Science. 1997 Dec 12;278(5345):1907-16. PMID:9417641
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