3gt9

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'''Unreleased structure'''
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{{Seed}}
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[[Image:3gt9.jpg|left|200px]]
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The entry 3gt9 is ON HOLD until Paper Publication
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{{STRUCTURE_3gt9| PDB=3gt9 | SCENE= }}
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Authors: Franklin, M.C., Fairbrother, W.J., Cohen, F.
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===Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic===
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Description: Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 09:39:48 2009''
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{{ABSTRACT_PUBMED_20189383}}
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==About this Structure==
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3GT9 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GT9 OCA].
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==Reference==
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<ref group="xtra">PMID:20189383</ref><ref group="xtra">PMID:17168540</ref><ref group="xtra">PMID:15485396</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Cohen, F.]]
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[[Category: Fairbrother, W J.]]
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[[Category: Franklin, M C.]]
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[[Category: Apoptosis]]
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[[Category: Apoptosis inhibition]]
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[[Category: Cytoplasm]]
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[[Category: Drug design]]
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[[Category: Metal-binding]]
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[[Category: Peptide complex]]
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[[Category: Peptidomimetic]]
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[[Category: Small molecule]]
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[[Category: Zinc]]
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[[Category: Zinc binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 14:13:08 2010''

Revision as of 12:13, 10 March 2010

Image:3gt9.jpg

Template:STRUCTURE 3gt9

Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic

Template:ABSTRACT PUBMED 20189383

About this Structure

3GT9 is a 2 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Cohen F, Koehler MF, Bergeron P, Elliott LO, Flygare JA, Franklin MC, Gazzard L, Keteltas SF, Lau K, Ly CQ, Tsui V, Fairbrother WJ. Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2229-33. Epub 2010 Feb 8. PMID:20189383 doi:10.1016/j.bmcl.2010.02.021
  • Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol. 2006 Sep 19;1(8):525-33. PMID:17168540 doi:10.1021/cb600276q
  • Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J. 2005 Jan 1;385(Pt 1):11-20. PMID:15485396 doi:10.1042/BJ20041108

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