Urate Oxidase
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | Urate oxidase (3bk8) is an enzyme belonging to the purine degratdation pathway, whose function is to prevent build-up of uric acid in the blood by catalyzing the oxidation of uric acid by molecular oxygen, producing 5-hydroxyisourate and hydrogen peroxide. This enzyme is found in many organisms, but not found in higher apes and humans. It has been suggested that this may be an evolutionary advantage, as uric acid is a strong anti-oxidant. This leads to the presence of fewer free radicals and therefore fewer instances of cancer as a result of aging. The lack of urate oxidase does, however, result in elevated levels of uric acid in the plasma, which can be fatal. Urate oxidase was first isolated from the fungus ''Aspergillus flavus''. | + | Urate oxidase (3bk8) is an enzyme belonging to the purine degratdation pathway, whose function is to prevent build-up of uric acid in the blood by catalyzing the oxidation of uric acid by molecular oxygen, producing 5-hydroxyisourate and hydrogen peroxide. This enzyme is found in many organisms, but not found in higher apes and humans. It has been suggested that this may be an evolutionary advantage, as uric acid is a strong anti-oxidant. This leads to the presence of fewer free radicals and therefore fewer instances of cancer as a result of aging. The lack of urate oxidase does, however, result in elevated levels of uric acid in the plasma, which can be fatal. Urate oxidase was first isolated from the fungus ''Aspergillus flavus'', but is now expressed in ''Saccharomyces cerevisiae'' for research and medical purposes. |
==Structure== | ==Structure== | ||
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| + | ==Function== | ||
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| + | ==Medical Implications== | ||
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| + | ==References== | ||
<applet load='3bk8' size='300' frame='true' align='right' caption='Urate oxidase (3bk8)' /><table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | <applet load='3bk8' size='300' frame='true' align='right' caption='Urate oxidase (3bk8)' /><table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | ||
Sonja Senekovic | Sonja Senekovic | ||
Revision as of 23:49, 10 March 2010
Contents |
Urate Oxidase
Introduction
Urate oxidase (3bk8) is an enzyme belonging to the purine degratdation pathway, whose function is to prevent build-up of uric acid in the blood by catalyzing the oxidation of uric acid by molecular oxygen, producing 5-hydroxyisourate and hydrogen peroxide. This enzyme is found in many organisms, but not found in higher apes and humans. It has been suggested that this may be an evolutionary advantage, as uric acid is a strong anti-oxidant. This leads to the presence of fewer free radicals and therefore fewer instances of cancer as a result of aging. The lack of urate oxidase does, however, result in elevated levels of uric acid in the plasma, which can be fatal. Urate oxidase was first isolated from the fungus Aspergillus flavus, but is now expressed in Saccharomyces cerevisiae for research and medical purposes.
Structure
Function
Medical Implications
References
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| Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell. |
Proteopedia Page Contributors and Editors (what is this?)
Sonja Senekovic, Michal Harel, Alexander Berchansky, David Canner, Andrea Gorrell, Joel L. Sussman
