8pch
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 8PCH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]]. Active as [[http://en.wikipedia.org/wiki/ | + | 8PCH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]]. Active as [[http://en.wikipedia.org/wiki/Cathepsin_H Cathepsin H]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.16 3.4.22.16]]. Structure known Active Site: ACT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=8PCH OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function., Guncar G, Podobnik M, Pungercar J, Strukelj B, Turk V, Turk D, Structure. 1998 Jan 15;6(1):51-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9493267 9493267] | Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function., Guncar G, Podobnik M, Pungercar J, Strukelj B, Turk V, Turk D, Structure. 1998 Jan 15;6(1):51-61. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9493267 9493267] | ||
| + | [[Category: Cathepsin H]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
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[[Category: protease]] | [[Category: protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:22:08 2007'' |
Revision as of 08:17, 30 October 2007
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CRYSTAL STRUCTURE OF PORCINE CATHEPSIN H DETERMINED AT 2.1 ANGSTROM RESOLUTION: LOCATION OF THE MINI-CHAIN C-TERMINAL CARBOXYL GROUP DEFINES CATHEPSIN H AMINOPEPTIDASE FUNCTION
Overview
BACKGROUND: Cathepsin H is a lysosomal cysteine protease, involved in, intracellular protein degradation. It is the only known, mono-aminopeptidase in the papain-like family and is reported to be, involved in tumor metastasis. The cathepsin H structure was determined in, order to investigate the structural basis for its aminopeptidase activity, and thus to provide the basis for structure-based design of synthetic, inhibitors. RESULTS: The crystal structure of native porcine cathepsin H, was determined at 2.1 A resolution. The structure has the typical, papain-family fold. The so-called mini-chain, the octapeptide EPQNCSAT, is, attached via a disulfide bond to the body of the enzyme and bound in a, narrowed active-site cleft, in the substrate-binding direction. The, mini-chain fills the ... [(full description)]
About this Structure
8PCH is a [Single protein] structure of sequence from [Sus scrofa]. Active as [Cathepsin H], with EC number [3.4.22.16]. Structure known Active Site: ACT. Full crystallographic information is available from [OCA].
Reference
Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function., Guncar G, Podobnik M, Pungercar J, Strukelj B, Turk V, Turk D, Structure. 1998 Jan 15;6(1):51-61. PMID:9493267
Page seeded by OCA on Tue Oct 30 10:22:08 2007
