Interleukin-10

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== '''Interlukin-10''' '''[[2H24]]''' ==
== '''Interlukin-10''' '''[[2H24]]''' ==
===Crystal structure of human IL-10===
===Crystal structure of human IL-10===
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This is a cytokine.<ref>PMID:16982608</ref> Cytokines function as....<ref>Reference 2</ref>
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[[Image:2h24.png|right|150px]]
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Interleukin-10 is a very powerful anti-inflammatory cytokine. It is also a cytokine synthesis inhibitory factor. These are the reasons that IL-10 is investigated for its role in patients with Rheumatoid Arthritis (RA) as well as those with osteoarthritis (OA).(Katsikis et al.)
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RA is an autoimmune disorder that affects the synovial tissues of the affected persons, via chronic synovitis. The chronic synovitis often results in joint destruction due to re-absorption of bone and (Katsikis et al and Nemec et al)
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Interleukin-10 is in the class [http://en.wikipedia.org/wiki/Cytokine cytokine].<ref>PMID:16982608</ref> Cytokines have many funtions such as from antiinflammatory cytokines,cytokine synthesis inhibitory factor and proinflammitory cytokines<ref>PMID:8163935</ref>.
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IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue.
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Interleukin-10 is a very powerful anti-inflammatory cytokine. It is also a cytokine synthesis inhibitory factor. These are the reasons that IL-10 is investigated for its role in patients with Rheumatoid Arthritis (RA) as well as those with osteoarthritis (OA)<ref>PMID:8163935</ref>.
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The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual. (Nemec)
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RA is an autoimmune disorder that affects the synovial tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage<ref>PMID:19758192</ref> <ref>PMID:8163935</ref>.
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IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue.
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The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual<ref>PMID:19758192</ref>.
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When IL-10 is blocked there is a increase in the proinflammatory cytokines, namely TFN-α and Il-1β
Make a link to the wiki website that talks about cytokines.
Make a link to the wiki website that talks about cytokines.
Make a link to RA
Make a link to RA
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<table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr>
<table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr>
Shelly Huebert
Shelly Huebert
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== '''References''' ==
== '''References''' ==

Revision as of 01:59, 18 March 2010

Contents

Interlukin-10 2H24

Crystal structure of human IL-10

Interleukin-10 is in the class cytokine.[1] Cytokines have many funtions such as from antiinflammatory cytokines,cytokine synthesis inhibitory factor and proinflammitory cytokines[2]. Interleukin-10 is a very powerful anti-inflammatory cytokine. It is also a cytokine synthesis inhibitory factor. These are the reasons that IL-10 is investigated for its role in patients with Rheumatoid Arthritis (RA) as well as those with osteoarthritis (OA)[3]. RA is an autoimmune disorder that affects the synovial tissues via chronic synovitis. Chronic synovitis often results in joint destruction due to re-absorption of bone and the distruction of cartilage[4] [5]. IL-10 is found to spontaneously be produce in synovial tissue of patients with RA and OA but not in normal synovial tissue. The variation in secretion of IL-10 is thought to be at about 75% under the control of the genetics of the individual[6]. When IL-10 is blocked there is a increase in the proinflammatory cytokines, namely TFN-α and Il-1β Make a link to the wiki website that talks about cytokines. Make a link to RA

Interleukin-10

Drag the structure with the mouse to rotate





Shelly Huebert
















References

  1. ↑ Yoon SI, Logsdon NJ, Sheikh F, Donnelly RP, Walter MR. Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J Biol Chem. 2006 Nov 17;281(46):35088-96. Epub 2006 Sep 18. PMID:16982608 doi:10.1074/jbc.M606791200
  2. ↑ Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med. 1994 May 1;179(5):1517-27. PMID:8163935
  3. ↑ Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med. 1994 May 1;179(5):1517-27. PMID:8163935
  4. ↑ Nemec P, Goldbergova MP, Gatterova J, Vasku A, Soucek M. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. Ann N Y Acad Sci. 2009 Sep;1173:501-8. PMID:19758192 doi:10.1111/j.1749-6632.2009.04625.x
  5. ↑ Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med. 1994 May 1;179(5):1517-27. PMID:8163935
  6. ↑ Nemec P, Goldbergova MP, Gatterova J, Vasku A, Soucek M. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. Ann N Y Acad Sci. 2009 Sep;1173:501-8. PMID:19758192 doi:10.1111/j.1749-6632.2009.04625.x

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[1] Ref1
Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.
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