Inositol 1,4,5-Trisphosphate Receptor
From Proteopedia
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<applet load='1n4k' size='300' frame='true' align='right' caption='Inositol 1,4,5-trisphosphate receptor. The red and orange molecule represent the ligand of the protein, inositol 1,4,5-trisphosphate' /> | <applet load='1n4k' size='300' frame='true' align='right' caption='Inositol 1,4,5-trisphosphate receptor. The red and orange molecule represent the ligand of the protein, inositol 1,4,5-trisphosphate' /> | ||
| - | Inositol 1,4,5-trisphosphate receptor binding protein is a ubiquitous protein involved in the Ca<sup>2+</sup> signalling processes in a variety of organisms < | + | Inositol 1,4,5-trisphosphate receptor binding protein is a ubiquitous protein involved in the Ca<sup>2+</sup> signalling processes in a variety of organisms <ref name="mainpaper">Bosanac I, Allatia JR, Mal TK, Chan J, Talarico S, Tong, FK, Tong KI, Yoshikawa, F, Furuichi T, Iwai M, Michikawa, T, Mikoshiba, Ikura M. Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature. 2002 Dec 12;420(6916):<696-700 PMID:12442173./ref> |
== Overall Structure == | == Overall Structure == | ||
The specific type of inositol 1,4,5-trisphosphate receptor (InsP<sub>3</sub>R) protein discussed here is the mouse type one InsP<sub>3</sub>R, also called InsP<sub>3</sub>R1. This polypeptide contains three major regions: the amino terminal inositol 1,4,5-trisphosphate (InsP<sub>3</sub>) binding region, the central modulatory region, and the carboxy-terminus channel region.<sup>1</sup> The protein forms an L-shaped structure composed of two asymmetric domains perpendicular to each other.<sup>[1]</sup> The N-terminal domain is made up of 12 β-strands and 2 single-turn helices, which come together to form a barrel.<sup>[1]</sup> The C-terminal end is quite different, consisting of a bundle made of eight α-helices.<sup>[1]</sup> The interface of the two domains is lined with basic residues and forms the receptor site for InsP<sub>3</sub>.<sup>[1]</sup> The overall structure with the ligand bound can be seen here: | The specific type of inositol 1,4,5-trisphosphate receptor (InsP<sub>3</sub>R) protein discussed here is the mouse type one InsP<sub>3</sub>R, also called InsP<sub>3</sub>R1. This polypeptide contains three major regions: the amino terminal inositol 1,4,5-trisphosphate (InsP<sub>3</sub>) binding region, the central modulatory region, and the carboxy-terminus channel region.<sup>1</sup> The protein forms an L-shaped structure composed of two asymmetric domains perpendicular to each other.<sup>[1]</sup> The N-terminal domain is made up of 12 β-strands and 2 single-turn helices, which come together to form a barrel.<sup>[1]</sup> The C-terminal end is quite different, consisting of a bundle made of eight α-helices.<sup>[1]</sup> The interface of the two domains is lined with basic residues and forms the receptor site for InsP<sub>3</sub>.<sup>[1]</sup> The overall structure with the ligand bound can be seen here: | ||
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== Function == | == Function == | ||
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| + | ==References== | ||
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Revision as of 23:52, 18 March 2010
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