Sandbox 173

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Rhodopsin is a G protein-coupled photoreceptor, with seven membrane-spanning α helices embedded in each disk of the outer segments of rod and cone cells in the vertebrate retina.
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Rhodopsin is a highly characterized G protein-coupled receptor found in the neurons of the retina and in rod photoreceptor cells. It is part of the Class A (Family 1) of G protein-coupled receptors, a superfamily of membrane receptors with seven transmembrane helices<ref>Article 6</ref>. G protein-coupled receptors mediate responses to visual, olfactory, hormonal, and neutransmitter signals among others<ref>Article 1</ref>.
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The chromophore 11-''cis''-retinal (light-absorbing pigment) is attached to opsin through a Schiff base linkage to Lysine 296.
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{{STRUCTURE_1u19| PDB=1u19 | SCENE= }}
{{STRUCTURE_1u19| PDB=1u19 | SCENE= }}
==Introduction==
==Introduction==

Revision as of 23:19, 25 March 2010

Rhodopsin is a highly characterized G protein-coupled receptor found in the neurons of the retina and in rod photoreceptor cells. It is part of the Class A (Family 1) of G protein-coupled receptors, a superfamily of membrane receptors with seven transmembrane helices[1]. G protein-coupled receptors mediate responses to visual, olfactory, hormonal, and neutransmitter signals among others[2].


PDB ID 1u19

Drag the structure with the mouse to rotate
1u19, resolution 2.20Å ()
Ligands: , , , , , , , ,
Non-Standard Residues:
Related: 1f88, 1hzx, 1l9h
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


Contents

Introduction

Structure

Characteristic G Protein-Coupled Receptor Architecture

About this structure[3].

Function

Light-Induced Visual Signal Transduction

Light absorption and G protein activation

Opsin

References

  • Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V. The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J Mol Biol. 2004 Sep 10;342(2):571-83. PMID:15327956 doi:10.1016/j.jmb.2004.07.044
  1. ↑ Article 6
  2. ↑ Article 1
  3. ↑ Testing out reference section, 2010 etc. Yay it works!
Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell.
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