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Sandbox 154
From Proteopedia
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== Introduction == | == Introduction == | ||
| - | Actin is | + | Actin is found in nearly all eukaryotic cells and is known primarily for its function as a structural and translocation protein. It also has an ATPase function, as it hydrolyzes ATP --> ADP + Pi as part of its assembly process. Microfilaments (F-actin) are |
| + | Actin occurs in two forms: globular actin (G-actin), the free monomeric units of actin, and filamentous actin (F-actin) which is the polymerized form. These two forms exist in a dynamic equilibrium with one another as ATP-associated polymerization and depolymerization occur continually on the F-actin structure. | ||
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| + | Actin is | ||
== Assembly == | == Assembly == | ||
Revision as of 02:26, 26 March 2010
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| 2zwh, resolution 3.30Å () | |||||||
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| Ligands: | , | ||||||
| Non-Standard Residues: | |||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Contents |
F-Actin
Filamentous actin (F-actin) is also referred to as microfilament [1] and is a highly conserved proteinous component found near ubiquitously in eukaryotic cytoskeletons. F-actin and other actin proteins generally provide a structural role to the cell.
Introduction
Actin is found in nearly all eukaryotic cells and is known primarily for its function as a structural and translocation protein. It also has an ATPase function, as it hydrolyzes ATP --> ADP + Pi as part of its assembly process. Microfilaments (F-actin) are Actin occurs in two forms: globular actin (G-actin), the free monomeric units of actin, and filamentous actin (F-actin) which is the polymerized form. These two forms exist in a dynamic equilibrium with one another as ATP-associated polymerization and depolymerization occur continually on the F-actin structure.
Actin is
Assembly
Structure
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History of the structure
The F-actin structure was discovered by Straub in 1942. The structure was speculated based on a low-resolution x-ray crystallograph found in 1990 by Holmes et al. The structure was deposited in the PDB databank in Decemeber 2008 by Oda et al. [2].
Monomeric Unit - G-actin
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Polymer F-actin
Structurally, F-actin appears like a double right-handed helix. It is actually composed of 13 actin units for every 6 left-handed turns, which each have 166° rotations, occurring over 350 Å . [3]. aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
Domains
Function
Enzymatic Role
Active Site
Ligand
Structural Role
References
- ↑ Microfilament - Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Microfilaments. Date accessed: March 16th, 2010.
- ↑ Oda T, Iwasa M, Aihara T, Maéda Y, and Narita A. 2009. The nature of the globular-to fibrous actin transition. Nature,457(7228):441-445. PMID: 19158791
- ↑ Holmes, K.C., Popp, D., Gebhard, W. and Kabsch, W. 1990. Atomic model of the actin filament. Nature,347(6288):44-49. PMID: 2395461
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