Sandbox 172
From Proteopedia
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{{STRUCTURE_1cza| PDB=1cza | SCENE=Sandbox_172/Mynewscene/1 }} | {{STRUCTURE_1cza| PDB=1cza | SCENE=Sandbox_172/Mynewscene/1 }} | ||
==Introduction== | ==Introduction== | ||
| - | Four types of hexokinase isozymes exist in the human biological system. They all serve to catalyze the exact same reaction in glycolysis even though they are encoded by different sets of genes. The hexokinase types I-III all have a high affinity for glucose and become subject to inhibition in the presence of glucose-6-phosphate- the first step reaction product in glycolysis. Hexokinase type IV varies from the other three hexokinase types as it is not inhibited by the production of glucose-6-phosphate and shows a lower affinity for glucose. | + | Four types of hexokinase isozymes exist in the human biological system. They all serve to catalyze the exact same reaction in glycolysis even though they are encoded by different sets of genes. The hexokinase types I-III all have a high affinity for glucose and become subject to inhibition in the presence of glucose-6-phosphate- the first step reaction product in glycolysis. Hexokinase type IV varies from the other three hexokinase types as it is not inhibited by the production of glucose-6-phosphate and shows a lower affinity for glucose. Hexokinase type I and II have the particular ability to bind to outer mitochondrial membrane, this binding happens both specifically and reversibly. |
| + | ==Structure== | ||
<table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | <table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. [[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | ||
Adrienne Lam | Adrienne Lam | ||
Revision as of 09:35, 26 March 2010
Hexokinase Type I
Hexokinase Type I is one of four hexokinase isoenzymes that participate in glycolysis. Hexokinase catalyzes the phosphorylation of glucose into glucose-6-phosphate (G6P) providing enough activation energy for the glycolytic process to start. Thus hexokinase allows the muscle cells to take up glucose in the blood and use it as an energy source for different actions and expenditures. Hexokinase Type I is mainly found in mammalian tissues; it is crucial enzyme in maintaining a downward concentration gradient to provide a steady influx of glucose into cells.
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| 1cza, resolution 1.90Å () | |||||||||
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| Ligands: | , , | ||||||||
| Activity: | Hexokinase, with EC number 2.7.1.1 | ||||||||
| Related: | 1hkb, 1hkc | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Introduction
Four types of hexokinase isozymes exist in the human biological system. They all serve to catalyze the exact same reaction in glycolysis even though they are encoded by different sets of genes. The hexokinase types I-III all have a high affinity for glucose and become subject to inhibition in the presence of glucose-6-phosphate- the first step reaction product in glycolysis. Hexokinase type IV varies from the other three hexokinase types as it is not inhibited by the production of glucose-6-phosphate and shows a lower affinity for glucose. Hexokinase type I and II have the particular ability to bind to outer mitochondrial membrane, this binding happens both specifically and reversibly.
Structure
| Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell. |
