Adenylosuccinate Synthetase
From Proteopedia
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==Introduction== | ==Introduction== | ||
| - | Adenylosuccinate Synthetase is an enzyme that is mainly involved in purine bio-synthesis. It does this by catalyzing the GTP dependent changeover of IMP and aspartic acid to AMP. <ref>PMID:1698173 </ref> | + | Adenylosuccinate Synthetase (AdSS) is an enzyme that is mainly involved in purine bio-synthesis. It does this by catalyzing the GTP dependent changeover of IMP and aspartic acid to AMP. <ref>PMID:1698173 </ref> |
==Structure== | ==Structure== | ||
<scene name='Sandbox_187/Secondary_structures/1'>Secondary Structure</scene> | <scene name='Sandbox_187/Secondary_structures/1'>Secondary Structure</scene> | ||
| - | + | The AdSS enzyme is a dimer consisting of two identical monomeric subunits. The main structural component of each monomer is a centrally located beta sheet that is comprised of 10 strands. Nine of the 10 strands are parallel while the 10th strand is anti-parallel with respect to the other 9 strands. There are also several other secondary structures including 2 small 3/10 helices, two anti-parallel sheets consisting of 2 and 3 strands respectively. Additionally there are 11 alpha helices. | |
==References== | ==References== | ||
Revision as of 21:54, 26 March 2010
Adenylosuccinate Synthetase
Introduction
Adenylosuccinate Synthetase (AdSS) is an enzyme that is mainly involved in purine bio-synthesis. It does this by catalyzing the GTP dependent changeover of IMP and aspartic acid to AMP. [1]
Structure
The AdSS enzyme is a dimer consisting of two identical monomeric subunits. The main structural component of each monomer is a centrally located beta sheet that is comprised of 10 strands. Nine of the 10 strands are parallel while the 10th strand is anti-parallel with respect to the other 9 strands. There are also several other secondary structures including 2 small 3/10 helices, two anti-parallel sheets consisting of 2 and 3 strands respectively. Additionally there are 11 alpha helices.
References
- ↑ Mukhopadhyay RP, Chandra AL. Keratinase of a streptomycete. Indian J Exp Biol. 1990 Jun;28(6):575-7. PMID:1698173
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