3i8a

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Revision as of 10:07, 31 March 2010

Image:3i8a.png

Template:STRUCTURE 3i8a

Staphylococcus aureus H30N, F98Y Dihydrofolate Reductase complexed with NADPH and 2,4-diamino-5-(3-(2,5-dimethoxyphenyl)prop-1-ynyl)-6-ethylpyrimidine (UCP120B)

Template:ABSTRACT PUBMED 20026215

About this Structure

3I8A is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

  • Frey KM, Lombardo MN, Wright DL, Anderson AC. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase. J Struct Biol. 2010 Apr;170(1):93-7. Epub 2009 Dec 21. PMID:20026215 doi:10.1016/j.jsb.2009.12.011

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