1gvz
From Proteopedia
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| - | [[Image:1gvz. | + | [[Image:1gvz.jpg|left|200px]]<br /><applet load="1gvz" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1gvz" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1gvz, resolution 1.42Å" /> | caption="1gvz, resolution 1.42Å" /> | ||
'''PROSTATE SPECIFIC ANTIGEN (PSA) FROM STALLION SEMINAL PLASMA'''<br /> | '''PROSTATE SPECIFIC ANTIGEN (PSA) FROM STALLION SEMINAL PLASMA'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GVZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus] with ACT and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 1GVZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus] with ACT and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Act Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: prostate specific antigen]] | [[Category: prostate specific antigen]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 15:40:40 2007'' |
Revision as of 13:30, 18 December 2007
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PROSTATE SPECIFIC ANTIGEN (PSA) FROM STALLION SEMINAL PLASMA
Overview
Prostate-specific kallikrein, a member of the gene family of serine, proteases, was initially discovered in semen and is the most useful serum, marker for prostate cancer diagnosis and prognosis. We report the crystal, structure at 1.42A resolution of horse prostate kallikrein (HPK). This is, the first structure of a serine protease purified from seminal plasma. HPK, shares extensive sequence homology with human prostate-specific antigen, (PSA), including a predicted chymotrypsin-like specificity, as suggested, by the presence of a serine residue at position S1 of the specificity, pocket. In contrast to other kallikreins, HPK shows a structurally, distinct specificity pocket. Its entrance is blocked by the kallikrein, loop, suggesting a possible protective or substrate-selective role for, this loop. The HPK structure seems to be in an inactivated state and, further processing might be required to allow the binding of substrate, molecules. Crystal soaking experiments revealed a binding site for Zn(2+), and Hg(2+), two known PSA inhibitors.
About this Structure
1GVZ is a Single protein structure of sequence from Equus caballus with ACT and GOL as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of a prostate kallikrein isolated from stallion seminal plasma: a homologue of human PSA., Carvalho AL, Sanz L, Barettino D, Romero A, Calvete JJ, Romao MJ, J Mol Biol. 2002 Sep 13;322(2):325-37. PMID:12217694
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