1gxb
From Proteopedia
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| - | [[Image:1gxb.gif|left|200px]]<br /> | + | [[Image:1gxb.gif|left|200px]]<br /><applet load="1gxb" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1gxb" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1gxb, resolution 2.65Å" /> | caption="1gxb, resolution 2.65Å" /> | ||
'''ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH PYROPHOSPHATE AND MAGNESIUM'''<br /> | '''ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH PYROPHOSPHATE AND MAGNESIUM'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GXB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus] with MG and POP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18. 2.4.2.18.] | + | 1GXB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus] with MG and POP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18. 2.4.2.18.] Known structural/functional Site: <scene name='pdbsite=PP1:Mg Binding Site For Chain D'>PP1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GXB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tryptophane biosynthesis]] | [[Category: tryptophane biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 15:44:07 2007'' |
Revision as of 13:34, 18 December 2007
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ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE IN COMPLEX WITH PYROPHOSPHATE AND MAGNESIUM
Overview
The crystal structure of the dimeric anthranilate, phosphoribosyltransferase (AnPRT) reveals a new category of, phosphoribosyltransferases, designated as class III. The active site of, this enzyme is located within the flexible hinge region of its two-domain, structure. The pyrophosphate moiety of phosphoribosylpyrophosphate is, co-ordinated by a metal ion and is bound by two conserved loop regions, within this hinge region. With the structure of AnPRT available, structural analysis of all enzymatic activities of the tryptophan, biosynthesis pathway is complete, thereby connecting the evolution of its, enzyme members to the general development of metabolic processes. Its, structure reveals it to have the same fold, topology, active site location, and type of association as class II nucleoside phosphorylases. At the, level of sequences, this relationship is mirrored by 13 structurally, invariant residues common to both enzyme families. Taken together, these, data imply common ancestry of enzymes catalysing reverse biological, processes--the ribosylation and deribosylation of metabolic pathway, intermediates. These relationships establish new links for enzymes, involved in nucleotide and amino acid metabolism.
About this Structure
1GXB is a Single protein structure of sequence from Sulfolobus solfataricus with MG and POP as ligands. Active as Transferase, with EC number 2.4.2.18. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural analysis of two enzymes catalysing reverse metabolic reactions implies common ancestry., Mayans O, Ivens A, Nissen LJ, Kirschner K, Wilmanns M, EMBO J. 2002 Jul 1;21(13):3245-54. PMID:12093726
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