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1gzt
From Proteopedia
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| - | [[Image:1gzt.gif|left|200px]]<br /> | + | [[Image:1gzt.gif|left|200px]]<br /><applet load="1gzt" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1gzt" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1gzt, resolution 1.30Å" /> | caption="1gzt, resolution 1.30Å" /> | ||
'''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''<br /> | '''PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GZT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with FUC and CA as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 1GZT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with FUC and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=FUA:Ca Binding Site For Chain D'>FUA</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: sugar-binding protein]] | [[Category: sugar-binding protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 15:48:55 2007'' |
Revision as of 13:39, 18 December 2007
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PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE
Overview
Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and, PA-IIL) contribute to the virulence of this pathogenic bacterium, which is, a major cause of morbidity and mortality in cystic fibrosis patients. The, crystal structure of PA-IIL in complex with fucose reveals a tetrameric, structure. Each monomer displays a nine-stranded, antiparallel b-sandwich, arrangement and contains two close calcium cations that mediate the, binding of fucose in a recognition mode unique among carbohydrate-protein, interactions. Experimental binding studies, together with theoretical, docking of fucose-containing oligosaccharides, are consistent with the, assumption that antigens of the Lewis a (Le(a)) series may be the, preferred ligands of this lectin. Precise knowledge of the lectin-binding, site should allow a better design of new antibacterial-adhesion, prophylactics.
About this Structure
1GZT is a Single protein structure of sequence from Pseudomonas aeruginosa with FUC and CA as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:12415289
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