1h58
From Proteopedia
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| - | [[Image:1h58.gif|left|200px]]<br /> | + | [[Image:1h58.gif|left|200px]]<br /><applet load="1h58" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1h58" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1h58, resolution 1.70Å" /> | caption="1h58, resolution 1.70Å" /> | ||
'''STRUCTURE OF FERROUS HORSERADISH PEROXIDASE C1A'''<br /> | '''STRUCTURE OF FERROUS HORSERADISH PEROXIDASE C1A'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1H58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana] with ACT, CA and HEM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] | + | 1H58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Armoracia_rusticana Armoracia rusticana] with ACT, CA and HEM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Known structural/functional Site: <scene name='pdbsite=CAA:Hem Binding Site For Chain A'>CAA</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H58 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: peroxidase]] | [[Category: peroxidase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 16:00:06 2007'' |
Revision as of 13:50, 18 December 2007
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STRUCTURE OF FERROUS HORSERADISH PEROXIDASE C1A
Overview
A molecular description of oxygen and peroxide activation in biological, systems is difficult, because electrons liberated during X-ray data, collection reduce the active centres of redox enzymes catalysing these, reactions. Here we describe an effective strategy to obtain crystal, structures for high-valency redox intermediates and present a, three-dimensional movie of the X-ray-driven catalytic reduction of a bound, dioxygen species in horseradish peroxidase (HRP). We also describe, separate experiments in which high-resolution structures could be obtained, for all five oxidation states of HRP, showing such structures with, preserved redox states for the first time.
About this Structure
1H58 is a Single protein structure of sequence from Armoracia rusticana with ACT, CA and HEM as ligands. Active as Peroxidase, with EC number 1.11.1.7 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The catalytic pathway of horseradish peroxidase at high resolution., Berglund GI, Carlsson GH, Smith AT, Szoke H, Henriksen A, Hajdu J, Nature. 2002 May 23;417(6887):463-8. PMID:12024218
Page seeded by OCA on Tue Dec 18 16:00:06 2007
Categories: Armoracia rusticana | Peroxidase | Single protein | Berglund, G.I. | Carlsson, G.H. | Hajdu, J. | Henriksen, A. | Smith, A.T. | Szoke, H. | ACT | CA | HEM | Ferrous state | Horseradish | Oxidoreductase
