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1gww
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1GWW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with GLC, MN and UDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ | + | 1GWW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with GLC, MN and UDP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_2.4.1.87 Transferred entry: 2.4.1.87]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.151 2.4.1.151]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GWW OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Transferred entry: 2.4.1.87]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
[[Category: Boix, E.]] | [[Category: Boix, E.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:32:27 2007'' |
Revision as of 08:27, 30 October 2007
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ALPHA-,1,3 GALACTOSYLTRANSFERASE- ALPHA-D-GLUCOSE COMPLEX
Overview
Bovine alpha-1,3-galactosyltransferase (alpha3GT) catalyzes the synthesis, of the alpha-galactose (alpha-Gal) epitope, the target of natural human, antibodies. It represents a family of enzymes, including the histo blood, group A and B transferases, that catalyze retaining glycosyltransfer, reactions of unknown mechanism. An initial study of alpha3GT in a crystal, form with limited resolution and considerable disorder suggested the, possible formation of a beta-galactosyl-enzyme covalent intermediate, (Gastinel, L. N., Bignon, C., Misra, A. K., Hindsgaul, O., Shaper, J. H., and Joziasse, D. H. (2001) EMBO J. 20, 638-649). Highly ordered structures, are described for complexes of alpha3GT with donor substrate, UDP-galactose, UDP- glucose, and two acceptor substrates, lactose and, ... [(full description)]
About this Structure
1GWW is a [Single protein] structure of sequence from [Bos taurus] with GLC, MN and UDP as [ligands]. Active as [Transferred entry: 2.4.1.87], with EC number [2.4.1.151]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural basis of ordered binding of donor and acceptor substrates to the retaining glycosyltransferase, alpha-1,3-galactosyltransferase., Boix E, Zhang Y, Swaminathan GJ, Brew K, Acharya KR, J Biol Chem. 2002 Aug 2;277(31):28310-8. Epub 2002 May 14. PMID:12011052
Page seeded by OCA on Tue Oct 30 10:32:27 2007
