2x1n

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===TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN===
===TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN===
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{{ABSTRACT_PUBMED_20146435}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:19472269</ref><references group="xtra"/>
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<ref group="xtra">PMID:20146435</ref><ref group="xtra">PMID:19472269</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Transferase]]
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Revision as of 06:12, 14 April 2010

Image:2x1n.png

Template:STRUCTURE 2x1n

TRUNCATION AND OPTIMISATION OF PEPTIDE INHIBITORS OF CDK2, CYCLIN A THROUGH STRUCTURE GUIDED DESIGN

Template:ABSTRACT PUBMED 20146435

About this Structure

2X1N is a 5 chains structure with sequences from Homo sapiens. This structure supersedes the now removed PDB entry 2wha. Full crystallographic information is available from OCA.

Reference

  • McIntyre NA, McInnes C, Griffiths G, Barnett AL, Kontopidis G, Slawin AM, Jackson W, Thomas M, Zheleva DI, Wang S, Blake DG, Westwood NJ, Fischer PM. Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors. J Med Chem. 2010 Mar 11;53(5):2136-45. PMID:20146435 doi:10.1021/jm901660c
  • Kontopidis G, Andrews MJ, McInnes C, Plater A, Innes L, Renachowski S, Cowan A, Fischer PM. Truncation and Optimisation of Peptide Inhibitors of Cyclin-Dependent Kinase 2-Cyclin A Through Structure-Guided Design. ChemMedChem. 2009 May 26. PMID:19472269 doi:10.1002/cmdc.200900093

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