1od1
From Proteopedia
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| - | [[Image:1od1. | + | [[Image:1od1.jpg|left|200px]]<br /><applet load="1od1" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1od1" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1od1, resolution 1.37Å" /> | caption="1od1, resolution 1.37Å" /> | ||
'''ENDOTHIAPEPSIN PD135,040 COMPLEX'''<br /> | '''ENDOTHIAPEPSIN PD135,040 COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OD1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] | + | 1OD1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] Known structural/functional Site: <scene name='pdbsite=CAT:Catalytic Aspartates'>CAT</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OD1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 17:26:37 2007'' |
Revision as of 15:16, 18 December 2007
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ENDOTHIAPEPSIN PD135,040 COMPLEX
Overview
The crystal structure of endothiapepsin complexed with the gem-diol, inhibitor PD-135,040 has been anisotropically refined to a resolution of, 1.37 A. The structure of this inhibitor complex is in agreement with, previous structures of endothiapepsin gem-diol inhibitor complexes that, have been used to develop proposed catalytic mechanisms. However, the, increase in resolution over previous structures confirms the presence of a, number of short hydrogen bonds within the active site that are likely to, play an important role in the catalytic mechanism. The presence of, low-barrier hydrogen bonds was indicated in a previous one-dimensional H, NMR spectrum.
About this Structure
1OD1 is a Protein complex structure of sequences from Cryphonectria parasitica with SO4 as ligand. Active as Endothiapepsin, with EC number 3.4.23.22 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The structure of endothiapepsin complexed with the gem-diol inhibitor PD-135,040 at 1.37 A., Coates L, Erskine PT, Mall S, Williams PA, Gill RS, Wood SP, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):978-81. Epub 2003, May 23. PMID:12777758
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