3is9

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Revision as of 06:08, 21 April 2010

Image:3is9.png

Template:STRUCTURE 3is9

Crystal structure of the HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor dimethyl 3,3'-(6-methoxy-6-oxohex-1-ene-1,1-diyl)bis(5-cyano-6-methoxybenzoate).

Template:ABSTRACT PUBMED 19775161

About this Structure

3IS9 is a 2 chains structure with sequences from Human immunodeficiency virus type 1 bh10. Full crystallographic information is available from OCA.

Reference

  • Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. J Med Chem. 2009 Oct 22;52(20):6467-73. PMID:19775161 doi:10.1021/jm901167t

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