1qlb
From Proteopedia
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| - | [[Image:1qlb. | + | [[Image:1qlb.jpg|left|200px]]<br /><applet load="1qlb" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1qlb" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1qlb, resolution 2.33Å" /> | caption="1qlb, resolution 2.33Å" /> | ||
'''RESPIRATORY COMPLEX II-LIKE FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES'''<br /> | '''RESPIRATORY COMPLEX II-LIKE FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Wolinella_succinogenes Wolinella succinogenes] with CA, HEM, FES, F3S, SF4, FAD, FMR and LMT as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Succinate_dehydrogenase Succinate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.1 1.3.99.1] | + | 1QLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Wolinella_succinogenes Wolinella succinogenes] with CA, HEM, FES, F3S, SF4, FAD, FMR and LMT as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Succinate_dehydrogenase Succinate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.1 1.3.99.1] Known structural/functional Sites: <scene name='pdbsite=FA1:Fad Covalent Bond To Protein For Chain A'>FA1</scene>, <scene name='pdbsite=FA2:Fad Covalent Bond To Protein For Chain D'>FA2</scene>, <scene name='pdbsite=FS1:Fe4s4 Fe Sulphur Centre Ligands For Chain B'>FS1</scene>, <scene name='pdbsite=FS2:Fe4s4 Fe Sulphur Centre Ligands For Chain E'>FS2</scene>, <scene name='pdbsite=FS3:Fe2s2 Fe Sulphur Centre Ligands For Chain B'>FS3</scene>, <scene name='pdbsite=FS4:Fe2s2 Fe Sulphur Centre Ligands For Chain E'>FS4</scene>, <scene name='pdbsite=FS5:Fe3s4 Fe Sulphur Centre Ligands For Chain B'>FS5</scene>, <scene name='pdbsite=FS6:Fe3s4 Fe Sulphur Centre Ligands For Chain E'>FS6</scene>, <scene name='pdbsite=HE1:Haem Axial Ligands For Chain C'>HE1</scene> and <scene name='pdbsite=HE2:Haem Axial Ligands For Chain F'>HE2</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QLB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: succinate dehydrogenase]] | [[Category: succinate dehydrogenase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 17:55:51 2007'' |
Revision as of 15:46, 18 December 2007
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RESPIRATORY COMPLEX II-LIKE FUMARATE REDUCTASE FROM WOLINELLA SUCCINOGENES
Overview
Fumarate reductase couples the reduction of fumarate to succinate to the, oxidation of quinol to quinone, in a reaction opposite to that catalysed, by the related complex II of the respiratory chain (succinate, dehydrogenase). Here we describe the crystal structure at 2.2 A resolution, of the three protein subunits containing fumarate reductase from the, anaerobic bacterium Wolinella succinogenes. Subunit A contains the site of, fumarate reduction and a covalently bound flavin adenine dinucleotide, prosthetic group. Subunit B contains three iron-sulphur centres. The, menaquinol-oxidizing subunit C consists of five membrane-spanning, primarily helical segments and binds two haem b molecules. On the basis of, the structure, we propose a pathway of electron transfer from the dihaem, cytochrome b to the site of fumarate reduction and a mechanism of fumarate, reduction. The relative orientations of the soluble and membrane-embedded, subunits of succinate:quinone oxidoreductases appear to be unique.
About this Structure
1QLB is a Protein complex structure of sequences from Wolinella succinogenes with CA, HEM, FES, F3S, SF4, FAD, FMR and LMT as ligands. Active as Succinate dehydrogenase, with EC number 1.3.99.1 Known structural/functional Sites: , , , , , , , , and . Full crystallographic information is available from OCA.
Reference
Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution., Lancaster CR, Kroger A, Auer M, Michel H, Nature. 1999 Nov 25;402(6760):377-85. PMID:10586875
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Categories: Protein complex | Succinate dehydrogenase | Wolinella succinogenes | Auer, M. | Kroeger, A. | Lancaster, C.R.D. | Michel, H. | CA | F3S | FAD | FES | FMR | HEM | LMT | SF4 | Citric acid cycle | Dihaem cytochrome b | Flavoprotein | Fumarate reductase | Iron-sulphur protein | Respiratory chain
