1qo8
From Proteopedia
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| - | [[Image:1qo8.gif|left|200px]]<br /> | + | [[Image:1qo8.gif|left|200px]]<br /><applet load="1qo8" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1qo8" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1qo8, resolution 2.15Å" /> | caption="1qo8, resolution 2.15Å" /> | ||
'''THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE'''<br /> | '''THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1QO8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Shewanella_frigidimarina Shewanella frigidimarina] with HEM and FAD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Succinate_dehydrogenase Succinate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.1 1.3.99.1] | + | 1QO8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Shewanella_frigidimarina Shewanella frigidimarina] with HEM and FAD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Succinate_dehydrogenase Succinate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.99.1 1.3.99.1] Known structural/functional Sites: <scene name='pdbsite=AC1:Hem Binding Site For Resdiue A601'>AC1</scene>, <scene name='pdbsite=AC2:Hem Binding Site For Resdiue A602'>AC2</scene>, <scene name='pdbsite=AC3:Hem Binding Site For Resdiue A603'>AC3</scene>, <scene name='pdbsite=AC4:Hem Binding Site For Resdiue A604'>AC4</scene>, <scene name='pdbsite=AC5:Fad Binding Site For Resdiue A605'>AC5</scene>, <scene name='pdbsite=AC6:Hem Binding Site For Resdiue D601'>AC6</scene>, <scene name='pdbsite=AC7:Hem Binding Site For Resdiue D602'>AC7</scene>, <scene name='pdbsite=AC8:Hem Binding Site For Residue D603'>AC8</scene>, <scene name='pdbsite=AC9:Hem Binding Site For Residue D604'>AC9</scene> and <scene name='pdbsite=BC1:Fad Binding Site For Residue D605'>BC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QO8 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 17:58:25 2007'' |
Revision as of 15:48, 18 December 2007
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THE STRUCTURE OF THE OPEN CONFORMATION OF A FLAVOCYTOCHROME C3 FUMARATE REDUCTASE
Overview
Fumarate reductases and succinate dehydrogenases play central roles in the, metabolism of eukaryotic and prokaryotic cells. A recent medium resolution, structure of the Escherichia coli fumarate reductase (Frd) has revealed, the overall organization of the membrane-bound complex. Here we present, the first high resolution X-ray crystal structure of a water-soluble, bacterial fumarate reductase in an open conformation. This structure, reveals a mobile domain that modulates substrate access to the active site, and provides new insights into the mechanism of this widespread and, important family of FAD-containing respiratory proteins.
About this Structure
1QO8 is a Single protein structure of sequence from Shewanella frigidimarina with HEM and FAD as ligands. Active as Succinate dehydrogenase, with EC number 1.3.99.1 Known structural/functional Sites: , , , , , , , , and . Full crystallographic information is available from OCA.
Reference
Open conformation of a flavocytochrome c3 fumarate reductase., Bamford V, Dobbin PS, Richardson DJ, Hemmings AM, Nat Struct Biol. 1999 Dec;6(12):1104-7. PMID:10581549
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