User:Ankit Vahia/sandbox1

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(Ligand-binding domain)
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[[Image:intactModelLargeText.jpg|frame|Bacterial chemotaxis receptor]]
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[[Image:intactModelLargeText.jpg|frame|T7 RNA polymerase in the late initiation phase]]
A [[CBI Molecule]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
A [[CBI Molecule]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
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Many bacteria can "smell" their surroundings and "choose" where to go. They detect molecules such as amino acids or sugars using receptors that bind these molecules and transmit a signal into the cell. This signal controls several proteins which ultimately control the direction of rotation of the motors that rotate the flagella. One direction causes the cell to continue swimming; the other direction causes the cell to tumble. When an attractant molecule binds, the receptor signals: "Things look good, keep swimming!" The opposite signal occurs when bacteria sense a repellant or less attractant molecules: "Time to tumble and try a new swimming direction."
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T7 RNA Polymerase is a single sub-unit DNA dependent RNA polymerase.
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A bacterial chemotaxis receptor is an unusually long alpha-helical structure. The attractant molecule (the ligand) binds near the top of this picture and sends a signal across the membrane into the cell to control proteins that bind near the bottom. This is a model of the structure of the receptor based on experimental structures of pieces of related proteins.
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=== 7 base DNA-RNA hybrid ===
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{{Clear}}
 
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<applet load='1wat' size='[450,338]' frame='true' align='right'
 
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caption='Aspartate receptor ligand binding domain (1wat)' scene='User:Lynmarie_K_Thompson/Sandbox_1/Loadedfrompdb/4'/>
 
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=== Ligand-binding domain ===
 
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The spinning protein (<scene name='User:Ankit_Vahia/sandbox1/T7-7mer_rna_scene_1/1'>TextToBeDisplayed</scene>) ) shows a 7 mer DNA-RNA hybrid as the enzyme is about to loose promoter contacts and transition into the more stable elongation phase.
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The spinning protein (<scene name='User:Ankit_Vahia/sandbox1/T7-7mer_rna_scene_1/1'>TextToBeDisplayed</scene>) ) is the ligand binding domain of the aspartate receptor with the aspartate ligand bound (LKT).
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Molecular Playground banner: A receptor protein used by bacteria to "smell" their environment.
Molecular Playground banner: A receptor protein used by bacteria to "smell" their environment.

Revision as of 19:32, 28 April 2010

T7 RNA polymerase in the late initiation phase
T7 RNA polymerase in the late initiation phase

A CBI Molecule being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.

T7 RNA Polymerase is a single sub-unit DNA dependent RNA polymerase.


7 base DNA-RNA hybrid

The spinning protein () ) shows a 7 mer DNA-RNA hybrid as the enzyme is about to loose promoter contacts and transition into the more stable elongation phase.


Molecular Playground banner: A receptor protein used by bacteria to "smell" their environment.

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Ankit Vahia

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