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Molecular playground/beta 2 microglobulin

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<applet size='[450,338]' frame='true' align='right'>
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<caption='β-2 Microglobulin' scene='User:Nick_Borotto/Sandbox_1/Basic_view/4'>
<caption='β-2 Microglobulin' scene='User:Nick_Borotto/Sandbox_1/Basic_view/4'>

Revision as of 15:56, 30 April 2010

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is a 12kd protein that self-assembles into amyloid fibrils in the presence of copper. This reaction is considered a likely cause for dialysis related amyloidosis; a disease where these fibrils build up in joints causing pain and eventually necessitating joint replacement.

Fibril assembly begins with the formation of a . This structures formation is initiated when copper binds near the , this binding causes structural shifts throughout the protein, creating two new . These planes interact in an antiparallel fashion forming the dimer.

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