1tf6
From Proteopedia
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| - | [[Image:1tf6. | + | [[Image:1tf6.jpg|left|200px]]<br /><applet load="1tf6" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1tf6" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1tf6, resolution 3.100Å" /> | caption="1tf6, resolution 3.100Å" /> | ||
'''CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION'''<br /> | '''CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1TF6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1TF6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. | + | 1TF6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. The following page contains interesting information on the relation of 1TF6 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Known structural/functional Sites: <scene name='pdbsite=AN1:Zn-Binding Site'>AN1</scene>, <scene name='pdbsite=AN2:Zn-Binding Site'>AN2</scene>, <scene name='pdbsite=AN3:Zn-Binding Site'>AN3</scene>, <scene name='pdbsite=AN4:Zn-Binding Site'>AN4</scene>, <scene name='pdbsite=AN5:Zn-Binding Site'>AN5</scene>, <scene name='pdbsite=AN6:Zn-Binding Site'>AN6</scene>, <scene name='pdbsite=DN1:Zn-Binding Site'>DN1</scene>, <scene name='pdbsite=DN2:Zn-Binding Site'>DN2</scene>, <scene name='pdbsite=DN3:Zn-Binding Site'>DN3</scene>, <scene name='pdbsite=DN4:Zn-Binding Site'>DN4</scene>, <scene name='pdbsite=DN5:Zn-Binding Site'>DN5</scene> and <scene name='pdbsite=DN6:'Zn-Binding'>DN6</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TF6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc finger protein]] | [[Category: zinc finger protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:01:55 2007'' |
Revision as of 15:52, 18 December 2007
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CO-CRYSTAL STRUCTURE OF XENOPUS TFIIIA ZINC FINGER DOMAIN BOUND TO THE 5S RIBOSOMAL RNA GENE INTERNAL CONTROL REGION
Overview
The crystal structure of the six NH2-terminal zinc fingers of Xenopus, laevis transcription factor IIIA (TFIIIA) bound with 31 bp of the 5S rRNA, gene promoter has been determined at 3.1 A resolution. Individual zinc, fingers are positioned differently in the major groove and across the, minor groove of DNA to span the entire length of the duplex. These results, show how TFIIIA can recognize several separated DNA sequences by using, fewer fingers than necessary for continuous winding in the major groove.
About this Structure
1TF6 is a Single protein structure of sequence from Xenopus laevis with ZN as ligand. The following page contains interesting information on the relation of 1TF6 with [Zinc Fingers]. Known structural/functional Sites: , , , , , , , , , , and . Full crystallographic information is available from OCA.
Reference
Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex., Nolte RT, Conlin RM, Harrison SC, Brown RS, Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2938-43. PMID:9501194
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