Molecular playground/beta 2 microglobulin

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Revision as of 20:43, 30 April 2010

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β-2 Microglobulin is a 12kd protein that self-assembles into amyloid fibrils in the presence of copper. This reaction is considered a likely cause for dialysis related amyloidosis; a disease where these fibrils build up in joints causing pain and eventually necessitating joint replacement.

Fibril assembly begins with the formation of a . This structures formation is initiated when copper binds near the , this binding causes structural shifts throughout the protein, creating two new . These planes interact in an antiparallel fashion forming the dimer.