User:Samantha B. Nicholls/Sandbox 1
From Proteopedia
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One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]. | One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground]. | ||
| - | + | The transmembrane region of influenza A viral protein M2 is a four helix bundle which has been shown to be responsible for proton transport across membranes. It is very high selective for protons over other ions and water and is necessary for the virus to regulate the pH inside the cell to mediate the release of it's viral DNA. This region has been extensively studied by several groups to determine M2’s structure and mechanisms, though there is little consensus on either. | |
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| - | <applet load='<scene name='User:Samantha_B._Nicholls/Sandbox_1/M2_tetramer_with_amantadine/1'>M2 with Inhibitor Amantadine Bound</scene>' | + | <applet load='<scene name='User:Samantha_B._Nicholls/Sandbox_1/M2_tetramer_with_amantadine/1'>M2 with Inhibitor Amantadine Bound</scene>' |
Revision as of 18:58, 4 May 2010
Transmembrane Domain of Influenza A Virus M2 Protein
One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
The transmembrane region of influenza A viral protein M2 is a four helix bundle which has been shown to be responsible for proton transport across membranes. It is very high selective for protons over other ions and water and is necessary for the virus to regulate the pH inside the cell to mediate the release of it's viral DNA. This region has been extensively studied by several groups to determine M2’s structure and mechanisms, though there is little consensus on either.
M2 Transmembrane Domain
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