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3l8v
From Proteopedia
Revision as of 08:58, 5 May 2010
Contents |
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor
Template:ABSTRACT PUBMED 20382527
Disease
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]
About this Structure
3L8V is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Williams DK, Chen XT, Tarby C, Kaltenbach R, Cai ZW, Tokarski JS, An Y, Sack JS, Wautlet B, Gullo-Brown J, Henley BJ, Jeyaseelan R, Kellar K, Manne V, Trainor GL, Lombardo LJ, Fargnoli J, Borzilleri RM. Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors. Bioorg Med Chem Lett. 2010 May 1;20(9):2998-3002. Epub 2010 Jan 20. PMID:20382527 doi:10.1016/j.bmcl.2010.01.042
Page seeded by OCA on Wed May 5 11:58:17 2010
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Sack, J. | Alternative splicing | Atp-binding | Chromosomal rearrangement | Disease mutation | Disulfide bond | Glycoprotein | Grb2 | Kinase | Membrane | Nucleotide-binding | Phosphoprotein | Polymorphism | Proto-oncogene | Receptor | Receptor tyrosine kinase | Shc | Signal transduction | Transferase | Transmembrane | Tyrosine-protein kinase
