Molecular Playground/Targeting Peptide

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[http://www.umass.edu/rotellogroup/ Rotello Group Website]
[http://www.umass.edu/rotellogroup/ Rotello Group Website]
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[[Image:DavesNanoparticle.jpg|thumb|left|Schematic representation of a 2 nm Au gold nanoparticle delivery vehicle, functionalized with the RGD peptide]]
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[[Image:DavesNanoparticle.jpg|thumb|left|Schematic representation of a 2 nm Au nanoparticle delivery vehicle, functioanlized with an RGD peptide (image by David Solfiell)]]

Revision as of 18:31, 5 May 2010

The RGD peptide is a popular peptide targeting motif used in experimental, nanoscale drug delivery vehicles (such as liposomes, micelles, dendrimers, nanoparticles, etc.) The RGD peptide binds specifically with cell adhesion molecules on the cell surface. Upregulation/overexpression of cell surface markers such as this integrin on certain kinds of cancer cells leads to selective accumulation of nanomaterial drug carriers within cancerous tissues, and targeted delivery of their payloads (drugs, contrast agents for imaging, etc.). Shown is the cyclic analogue of the RGD peptide complexed with alpha 5 Integrin.

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Rotello Group Website

Schematic representation of a 2 nm Au nanoparticle delivery vehicle, functioanlized with an RGD peptide (image by David Solfiell)
Schematic representation of a 2 nm Au nanoparticle delivery vehicle, functioanlized with an RGD peptide (image by David Solfiell)

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David Solfiell

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