1vyb
From Proteopedia
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| - | [[Image:1vyb. | + | [[Image:1vyb.jpg|left|200px]]<br /><applet load="1vyb" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1vyb" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1vyb, resolution 1.80Å" /> | caption="1vyb, resolution 1.80Å" /> | ||
'''ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P'''<br /> | '''ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1VYB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4, SO3 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. | + | 1VYB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4, SO3 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VYB OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:23:11 2007'' |
Revision as of 16:13, 18 December 2007
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ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P
Overview
The human L1 endonuclease (L1-EN) is encoded by the non-LTR, retrotransposon LINE-1 (L1). L1 is responsible for more than 1.5 million, retrotransposition events in the history of the human genome, contributing, more than a quarter to human genomic DNA (L1 and Alu elements). L1-EN is, related to the well-understood human DNA repair endonuclease APE1, and its, nicking specificity is a major determinant for retrotransposon integration, site selection. The crystal structure of human L1 endonuclease is the, first of a retrotransposon-encoded protein and a prototype for, retrotransposon-encoded endonucleases involved in target-primed reverse, transcription. Structure-based endonuclease alignments reveal a conserved, threonine in addition to previously identified invariant residues and, suggest that DNA recognition proceeds via the accommodation of an, extrahelical nucleotide within a pocket of the enzyme. The present, analysis will help to refine phylogenetic and functional relationships, among metal-dependent phosphohydrolases and provides a basis for, manipulating non-LTR retrotransposon integration site selection.
About this Structure
1VYB is a Single protein structure of sequence from Homo sapiens with SO4, SO3 and GOL as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon., Weichenrieder O, Repanas K, Perrakis A, Structure. 2004 Jun;12(6):975-86. PMID:15274918
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