This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1hav
From Proteopedia
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1HAV is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ | + | 1HAV is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]]. Structure known Active Sites: PRO, RNA and S1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HAV OCA]]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Hepatitis a virus]] | [[Category: Hepatitis a virus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Bergmann, E.M.]] | [[Category: Bergmann, E.M.]] | ||
[[Category: James, M.N.G.]] | [[Category: James, M.N.G.]] | ||
| Line 24: | Line 25: | ||
[[Category: thiol protease]] | [[Category: thiol protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:40:13 2007'' |
Revision as of 08:35, 30 October 2007
|
HEPATITIS A VIRUS 3C PROTEINASE
Overview
The virally encoded 3C proteinases of picornaviruses process the, polyprotein produced by the translation of polycistronic viral mRNA. The, X-ray crystallographic structure of a catalytically active mutant of the, hepatitis A virus (HAV) 3C proteinase (C24S) has been determined. Crystals, of this mutant of HAV 3C are triclinic with unit cell dimensions a = 53.6, A, b = 53.5 A, c = 53.2 A, alpha = 99.1 degrees, beta = 129.0 degrees, and, gamma = 103.3 degrees. There are two molecules of HAV 3C in the unit cell, of this crystal form. The structure has been refined to an R factor of, 0.211 (Rfree = 0.265) at 2.0-A resolution. Both molecules fold into the, characteristic two-domain structure of the chymotrypsin-like serine, proteinases. The active-site and substrate-binding regions are ... [(full description)]
About this Structure
1HAV is a [Protein complex] structure of sequences from [Hepatitis a virus] with CL as [ligand]. Active as [RNA-directed RNA polymerase], with EC number [2.7.7.48]. Structure known Active Sites: PRO, RNA and S1. Full crystallographic information is available from [OCA].
Reference
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition., Bergmann EM, Mosimann SC, Chernaia MM, Malcolm BA, James MN, J Virol. 1997 Mar;71(3):2436-48. PMID:9032381
Page seeded by OCA on Tue Oct 30 10:40:13 2007
