1w07

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[[Image:1w07.gif|left|200px]]<br />
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[[Image:1w07.gif|left|200px]]<br /><applet load="1w07" size="450" color="white" frame="true" align="right" spinBox="true"
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<applet load="1w07" size="450" color="white" frame="true" align="right" spinBox="true"
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caption="1w07, resolution 2.00&Aring;" />
caption="1w07, resolution 2.00&Aring;" />
'''ARABIDOPSIS THALIANA ACYL-COA OXIDASE 1'''<br />
'''ARABIDOPSIS THALIANA ACYL-COA OXIDASE 1'''<br />
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==About this Structure==
==About this Structure==
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1W07 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with CA, CL, PT and FAD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Acyl-CoA_oxidase Acyl-CoA oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.6 1.3.3.6] Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W07 OCA].
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1W07 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with CA, CL, PT and FAD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Acyl-CoA_oxidase Acyl-CoA oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.6 1.3.3.6] Known structural/functional Site: <scene name='pdbsite=AC1:Pt Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W07 OCA].
==Reference==
==Reference==
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[[Category: peroxisomal beta-oxidation]]
[[Category: peroxisomal beta-oxidation]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 17:21:18 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:25:08 2007''

Revision as of 16:15, 18 December 2007


1w07, resolution 2.00Å

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ARABIDOPSIS THALIANA ACYL-COA OXIDASE 1

Overview

The peroxisomal acyl-CoA oxidase family plays an essential role in lipid, metabolism by catalyzing the conversion of acyl-CoA into trans-2-enoyl-CoA, during fatty acid beta-oxidation. Here, we report the X-ray structure of, the FAD-containing Arabidopsis thaliana acyl-CoA oxidase 1 (ACX1), the, first three-dimensional structure of a plant acyl-CoA oxidase. Like other, acyl-CoA oxidases, the enzyme is a dimer and it has a fold resembling that, of mammalian acyl-CoA oxidase. A comparative analysis including mammalian, acyl-CoA oxidase and the related tetrameric mitochondrial acyl-CoA, dehydrogenases reveals a substrate-binding architecture that explains the, observed preference for long-chained, mono-unsaturated substrates in ACX1., Two anions are found at the ACX1 dimer interface and for the first time, the presence of a disulfide bridge in a peroxisomal protein has been, observed. The functional differences between the peroxisomal acyl-CoA, oxidases and the mitochondrial acyl-CoA dehydrogenases are attributed to, structural differences in the FAD environments.

About this Structure

1W07 is a Single protein structure of sequence from Arabidopsis thaliana with CA, CL, PT and FAD as ligands. Active as Acyl-CoA oxidase, with EC number 1.3.3.6 Known structural/functional Site: . Full crystallographic information is available from OCA.

Reference

Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism., Pedersen L, Henriksen A, J Mol Biol. 2005 Jan 21;345(3):487-500. PMID:15581893

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